4 papers6 findings
An in silico study links genetically predicted higher serum urate to greater risks of coronary artery disease, coronary heart disease, myocardial infarction and heart failure. Its association with atrial fibrillation is not statistically significant after Hartung–Knapp adjustment.
6 findings in 2 papers since July 2026
SGLT2 inhibitors
downin humans1
SGLT2 inhibitors decrease serum urate in humans.
“Serum urate fell in the patients with preserved diuresis but not in those who were anuric”
Human trialin peritoneal dialysis patients with preserved diuresisn = 7
SGLT2 inhibitors as a strategy for volume management in peritoneal dialysis: a case series
Frontiers in nephrology29 Sep 2026
Atrial fibrillation
upin silico1OR 1.07
Serum urate raises the risk of atrial fibrillation in silico (OR = 1.07, 95% CI: 1.02-1.12).
“atrial fibrillation (OR = 1.07, 95% CI: 1.02-1.12)”
In silicogenetically predicted higher serum urate; not significant after Hartung-Knapp adjustment1.5 mg/dL increase
Frontiers in endocrinology24 Jul 2026
Heart failure
upin silico1OR 1.08
Serum urate raises the risk of heart failure in silico (OR = 1.08, 95% CI: 1.05-1.11).
“heart failure based on IVW estimates (OR = 1.08, 95% CI: 1.05-1.11)”
In silicogenetically predicted higher serum urate, IVW estimates1.5 mg/dL increase
Frontiers in endocrinology24 Jul 2026
Coronary artery disease
upin silico1OR 1.17
Serum urate raises the risk of coronary artery disease in silico (OR = 1.17, 95% CI: 1.08-1.26).
“coronary artery disease (OR = 1.17, 95% CI: 1.08-1.26)”
In silicogenetically predicted higher serum urate1.5 mg/dL increase
Frontiers in endocrinology24 Jul 2026
Myocardial infarction
upin silico1OR 1.13
Serum urate raises the risk of myocardial infarction in silico (OR = 1.13, 95% CI: 1.08-1.17).
“myocardial infarction (OR = 1.13, 95% CI: 1.08-1.17)”
In silicogenetically predicted higher serum urate1.5 mg/dL increase
Frontiers in endocrinology24 Jul 2026
Coronary heart disease
upin silico1OR 1.13
Serum urate raises the risk of coronary heart disease in silico (OR = 1.13, 95% CI: 1.10-1.15).
“genetically predicted higher serum urate was associated with increased risks of coronary heart disease (OR = 1.13, 95% CI: 1.10-1.15)”
In silicogenetically predicted higher serum urate1.5 mg/dL increase
Frontiers in endocrinology24 Jul 2026
In an observational study of 116 patients, detected urate was linked to odds of high-risk plaque 4.91 times those without detected urate.In an observational study of 116 patients, detected urate was linked to odds of high-risk plaque 4.91 times those without detected urate.