Serum insulin

1. Acarbose decreases serum insulin in humans (postprandial, at 100 and 200 mg doses) (maximal inhibitory effect 69 min after breakfast).

   “One hundred and 200 mg of BAY g 5421 were equally inhibitory-effective on the serum insulin levels”

   Human trialpostprandial, at 100 and 200 mg doses100 and 200 mgmalesn = 24

   The effects of the alpha-glucosidase inhibitor BAY g 5421 (Acarbose) on postprandial blood glucose, serum insulin, and triglyceride levels: dose-time-response relationships in man

   Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie·Apr 23, 1979

2. Acarbose increases serum insulin in mice (relative to old controls).

   “higher levels of insulin, InsRs and H4K8ac relative to the old controls”

   Animalsrelative to old controls20mg/kg/d3 to 9 monthsn = 9

   Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8

   Brain research·Jan 31, 2015

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1. Caloric restriction decreases serum insulin in rats after glucose injection.

   “In the W-CR and Tg-AL rats, the serum insulin and pY-IR levels were lower than those in the W-AL rats.”

   Animalsafter glucose injection30% CR diet from 6 weeks of agewhite adipose tissuemales

   Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling

   Experimental gerontology·Jul 29, 2009

2. Caloric restriction decreases serum insulin in mice.

   “the lowest concentrations of serum insulin and IGF-1 were observed in 18% calorie-restricted mice.”

   Animals18%24 wk

   Effect of exercise and calorie restriction on biomarkers of aging in mice

   American journal of physiology. Regulatory, integrative and comparative physiology·Mar 5, 2008

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1. Laser acupuncture decreases serum insulin in humans (visceral obesity in postmenopausal women) (P < 0.05).

   “Laser acupoints were associated with an improvement in visceral fat and serum insulin levels in postmenopausal women”

   Human trialvisceral obesity in postmenopausal womenfemalesn = 40

   Effect of Laser Acupoints on Hormonal Changes and Visceral Obesity in Postmenopausal Women: Randomized Controlled Trial

   Sudan Journal of Medical Sciences·Apr 7, 2026

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1. Ketogenic diet decreases serum insulin in humans (short-term hypocaloric diet) (-54%).

   “KD, but not ND, markedly reduced serum insulin concentrations (-54%)”

   Human trialshort-term hypocaloric diet

   Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD

   Journal of hepatology·Feb 6, 2026

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1. Resveratrol decreases serum insulin in humans (obesity and insulin resistance).

   “Notably, serum insulin and triglycerides significantly decreased in the resveratrol group compared to placebo.”

   Human trialobesity and insulin resistancetwo monthsn = 32

   Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance

   European journal of nutrition·Dec 8, 2025

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1. Dietary restriction decreases serum insulin in HCVcp transgenic mice fed 70% of control diet.

   “Serum insulin and insulin-like growth factor 1 levels, as well as hepatic expression of insulin receptor substrate 1/2, phosphatidylinositol-3 kinase, and serine/threonine-protein kinase AKT, were downregulated by DR.”

   Animalsin HCVcp transgenic mice fed 70% of control diet70% of control diet15 monthsmales

   Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice

   Liver cancer·Jul 10, 2020

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1. Rapamycin showed no clear effect on serum insulin in mice (none of the nine inbred strains).

   “Although pancreatic insulin content was reduced by rapamycin in seven strains, none showed reduced serum insulin values.”

   Animalsnone of the nine inbred strains

   Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jul 6, 2019

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1. Acarbose + glibenclamide decreases serum insulin in humans (compared with glibenclamide monotherapy) (AUC 243.5 vs 383.4 hr x microU/ml; p=0.02).

   “Serum insulin levels (mean AUC(7.30-12 h)) observed with acarbose plus glibenclamide combination therapy were significantly lower”

   Human trialcompared with glibenclamide monotherapyn = 84

   The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles: additive blood glucose lowering effect and decreased hypoglycaemia

   Diabetes, nutrition & metabolism·Jun 1, 2002

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1. Miglitol showed no clear effect on serum insulin in humans after a 75 g oral glucose load.

   “Serum insulin did not change significantly.”

   Human trialafter a 75 g oral glucose load100 mgn = 9

   The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism?

   British journal of clinical pharmacology·Sep 1, 1990

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1. PIK3R2 increases serum insulin in mice (p85β mutant transgenic mice).

   “p85β gene mutation causes increased serum insulin”

   Animalsp85β mutant transgenic mice

   C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

   Scientific reports·Sep 3, 2019

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