SERCA

5 papers study it32 more mention it2 findings

Humans1
Animals4

Interventions

1

CDN1163

upin mice1+41% reduction prevented

1 study

CDN1163 increases SERCA in mice (41% reduction prevented).
“maximal SERCA activity was reduced 41% in gastrocnemius muscle in vehicle-treated mice but maintained in old CDN1163 treated mice”
Animalsaging, 26-month-old micegastrocnemius muscle10 monthsmales
Restoration of Sarcoplasmic Reticulum Ca²⁺ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
International journal of molecular sciencesDec 22, 2020

More on CDN1163

Upstream

1

Chronic obstructive pulmonary disease

downin humans1

1 study

Chronic obstructive pulmonary disease decreases SERCA in humans.
“The maximal SR Ca2+ ATPase (SERCA) activity was significantly reduced in advanced COPD as compared to healthy controls.”
Humansadvanced COPD vs healthy controlsskeletal muscle
Sarcopenia in pulmonary diseases is associated with elevated sarcoplasmic reticulum stress and myonuclear disorganization
Histochemistry and cell biologyOct 19, 2021

More on Chronic obstructive pulmonary disease

Funding

1 grant since 2019

US Department of Veterans Affairs

Activation of the Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) as a Therapeutic Intervention for Sarcopenia
US Department of Veterans AffairsOklahoma City Va Medical Center2019–2023

Latest

5 papers in 12 months

Journal of Cachexia, Sarcopenia and MuscleJan 28

PrPC Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging

Experiments in miceCellular homeostasis

Histochemistry and Cell BiologyOct 20

Sarcopenia in pulmonary diseases is associated with elevated sarcoplasmic reticulum stress and myonuclear disorganization

Cross-sectional study in peopleEndoplasmic reticulum

Journal of Cachexia, Sarcopenia and MuscleSep 25

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

Experiments in miceMuscle weakness

International Journal of Molecular SciencesDec 31

Restoration of Sarcoplasmic Reticulum Ca²⁺ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Experiments in miceMuscle

Journal of Muscle Research and Cell MotilityDec 1

Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months

Experiments in ratsMuscle

International Archives of OtorhinolaryngologyAug 15

Differential Expression of SERCA and Myosin Heavy Chain Isoforms in Rat Laryngeal Muscles

Experiments in ratsMuscle

bioRxivMar 11

Thermoregulatory Constraints on Regenerative Competence: Evolutionary Trade-Offs Between Metabolic Homeostasis and Tissue Repair

Preprint: commentaryCellular homeostasis

Nature MetabolismDec 4

Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy

Experiments in miceAutophagy

npj AgingNov 27

Simple molecules make difference: short peptides play a novel role in slowing senescence

ReviewInterventions

AHA Scientific Sessions 2025 AbstractNov 3

Estrogen Deficiency Exacerbates Cardiac Dysfunction in a Female Mouse Model of Cardiometabolic Injury Via Phospholamban Modulation

Experiments in miceMechanisms