Senescence gene signature
3 papers2 findings
- Humans1
- In silico2
Associations
2SGLT2 inhibitors
upin humans1
1 study
SGLT2 inhibitors
upin humans1
Senescence gene signature predicts SGLT2 inhibitors in humans (AUC = 0.81).
“Subgroup analysis of peripheral blood samples confirmed the predictive pattern (AUC = 0.81).”
Humansin peripheral blood samplesperipheral blood
AHA Scientific Sessions 2025 abstract3 Nov 2025
Stress-response enrichment
upin silico1
1 study
Stress-response enrichment
upin silico1
Senescence gene signature is associated with stress-response enrichment in silico.
“various gene signatures used to identify senescent cells in the literature also enrich for stress responses, and are inadequate for universally and exclusively identifying senescent samples.”
In silicoPublished senescence gene signatures; inadequate for universal and exclusive identification of senescent samples
Mosaic Regulation of Stress Pathways Underlies Senescent Cell Heterogeneity
bioRxiv (Cold Spring Harbor Laboratory)4 Oct 2024Preprint
Latest
3 in 12 monthsbioRxiv
Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids
Preprint: study in peopleExtracellular matrix remodelling
Nature Aging
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter
Experiments in animalsInterventions
AHA Scientific Sessions 2025 Abstract
Senescence Gene Signatures Predict Response to SGLT2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Systematic Review and Transcriptomic Meta-Analysis
Computational studyHeart failure with preserved ejection fraction
GeroScience
Prognostic impact of a senescence gene signature in multiple myeloma
Computational studyBiomarkers
bioRxiv
Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans
Preprint: study in peopleMechanisms
bioRxiv
Mosaic Regulation of Stress Pathways Underlies Senescent Cell Heterogeneity
Preprint: computational studyCell cycle regulation