Purine

2 papers

Animals1

Latest

39 in 12 months

Orvosi Hetilap11 Oct

The gut-muscle axis and the role of Roseburia inulinivorans in age-related muscle loss: a narrative review

ReviewMuscle

bioRxiv2 Oct

Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies

Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.

Preprint: experiments in fliesPurine metabolism

International Journal of Molecular Sciences28 Sep

ADA loss impairs DNA repair and spurs senescence in astrocytes

Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting…Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting 53BP1-mediated repair.

Experiments in human cellsDNA repair

Frontiers in Nutrition18 Sep

Insulin resistance and uric acid-related metabolic disturbances jointly identify individuals at high risk of advanced cardiovascular-kidney-metabolic syndrome: a population-based study

Cross-sectional study of 8,939 peopleCardiovascular-kidney-metabolic syndrome

Research Square9 Sep

L-Aspartic acid is a Core Metabolite Mediating the Anti-aging Effect of Probiotics in Caenorhabditis elegans

Preprint: experiments in wormsInterventions

bioRxiv9 Sep

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

Preprint: experiments in fliesPurine metabolism

Annals of Medicine3 Sep

The multiple composite risk index estimates the risks of sarcopenia and comorbidities: unveiling the role of oxidative balance score

Cohort study of 8,537 peopleOxidative balance score

Journal of Alzheimer's Disease31 Aug

Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults

Cohort study of 1,039 peopleTau

Frontiers in Endocrinology29 Aug

A distinct serum metabolic profile characterizes osteosarcopenia: identifying potential metabolic biomarkers

Cross-sectional study of 104 peopleOsteosarcopenia

Research Square26 Aug

Sex- and age-dependent energetic dysfunction in LRRK2 G2019S Parkinson’s model revealed by structural analysis of RGC dendritic architecture and metabolic profiling of optic nerve

Preprint: experiments in micePurine metabolism