2 papers3 findings
foxo
downin flies1
foxo decreases protein aggregates in flies.
“The transcription factor FOXO and its target 4E-BP remove damaged proteins at least in part via the autophagy/lysosome system”
Model organismsmuscle
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
Cell24 Nov 2010
age-1
downin worms1
age-1 decreases protein aggregates in worms.
“expressing Q82 in the background of age-1 mutant animals that exhibit an extended lifespan. We observed a dramatic delay of polyQ toxicity and appearance of protein aggregates”
Model organismsexpressing Q82 in age-1 mutant animals
Proceedings of the National Academy of Sciences of the United States of America16 Jul 2002
Polyglutamine-expansion proteins
upin worms1
Polyglutamine-expansion proteins increase protein aggregates in worms.
“young adults exhibit a sharp boundary at 35-40 glutamines associated with the appearance of protein aggregates and loss of motility”
Model organismsexpressed in body wall muscle cellsmuscle
Proceedings of the National Academy of Sciences of the United States of America16 Jul 2002
National Institute on AgingUS$4.5m
National Institute on AgingColorado State UniversityUS$741.8k2024–2029
National Institute on AgingUniversity of Nebraska Medical CenterUS$422.1k2026–2028
Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue
National Institute on AgingUniv of Arkansas for Med ScisUS$470.3k2023–2028
Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.