foxo

5 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

8 independent labs in 3 countries

Funders: National Institutes of Health and others

Model organisms4

Effects

Lifespan

upin flies1upin reviews1

2 studies

foxo improves lifespan.
“forkhead transcription factor FOXO, control the expression of many autophagy-related genes and are important for life-span extension”
Review
Transcriptional and epigenetic regulation of autophagy in aging
Autophagy1 Jan 2015
foxo extends lifespan in flies.
“Both FOXO and 4E-BP delay muscle functional decay and extend life span.”
Model organismsmuscle
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
Cell24 Nov 2010

Antimicrobial peptide expression

downin Hydra1

1 study

foxo decreases antimicrobial peptide expression in Hydra.
“In addition, it caused down-regulation of stem cell genes and antimicrobial peptide (AMP) expression.”
Model organismsfoxO down-regulation
FoxO is a critical regulator of stem cell maintenance in immortal Hydra
Proceedings of the National Academy of Sciences of the United States of America12 Nov 2012

More on Antimicrobial peptide expression

Population growth rate

downin Hydra1

1 study

foxo decreases population growth rate in Hydra.
“foxO down-regulation led to an increase in the number of terminally differentiated cells, resulting in a drastically reduced population growth rate.”
Model organismsfoxO down-regulation
FoxO is a critical regulator of stem cell maintenance in immortal Hydra
Proceedings of the National Academy of Sciences of the United States of America12 Nov 2012

Interstitial stem cell and progenitor cell proliferation

upin Hydra1

1 study

foxo increases interstitial stem cell and progenitor cell proliferation in Hydra.
“foxO overexpression increased interstitial stem cell and progenitor cell proliferation”
Model organismsfoxO overexpression
FoxO is a critical regulator of stem cell maintenance in immortal Hydra
Proceedings of the National Academy of Sciences of the United States of America12 Nov 2012

Feeding behavior

downin flies1

1 study

foxo decreases feeding behavior in flies.
“FOXO/4E-BP signaling in muscles decreases feeding behavior and the release of insulin from producing cells”
Model organismsmuscle
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
Cell24 Nov 2010

Protein aggregates

downin flies1

1 study

foxo decreases protein aggregates in flies.
“The transcription factor FOXO and its target 4E-BP remove damaged proteins at least in part via the autophagy/lysosome system”
Model organismsmuscle
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
Cell24 Nov 2010