Polyglutamine-expansion proteins

1. Polyglutamine-expansion proteins increase protein aggregates in worms.

   “young adults exhibit a sharp boundary at 35-40 glutamines associated with the appearance of protein aggregates and loss of motility”

   Model organismsexpressed in body wall muscle cellsmuscle

   The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

   Proceedings of the National Academy of Sciences of the United States of America·16 Jul 2002

More on Protein aggregates

1. Polyglutamine-expansion proteins impair motility in worms.

   “young adults exhibit a sharp boundary at 35-40 glutamines associated with the appearance of protein aggregates and loss of motility”

   Model organismsexpressed in body wall muscle cellsmuscle

   The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

   Proceedings of the National Academy of Sciences of the United States of America·16 Jul 2002