What does the research say about proteasomal degradation?

Proteasomal degradation

There is 1 paper on proteasomal degradation in aging research: none in people yet, 1 in animals. The newest story, Nov 12, 2026: “Boosting a gene-regulating enzyme extended lifespan in worms”.

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1 paper studies it129 more mention it

12 new papers in 30 daysSee all 130 papers on proteasomal degradation

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49 papers in 12 months

bioRxivNov 12

Boosting a gene-regulating enzyme extended lifespan in worms

Worm experiments showed that increasing the enzyme preserved health during aging and strengthened stress responses.Worm experiments showed that increasing the enzyme preserved health during aging and strengthened stress responses.

Preprint: worm studyInterventions

Paper

Pharmacological ResearchNov 5

Protein may limit steroid-related bone damage in animals

Increasing a protein involved in fat metabolism counteracted steroid-related damage and restored the internal structure of the top of the thighbone in animal experiments.Increasing a protein involved in fat metabolism counteracted steroid-related damage and restored the internal structure of the top of the thighbone in animal experiments.

Animal studyBones and joints

Paper

NPJ AgingNov 3

Protein loss disrupts nuclear structure in primate cells

Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging…Restoring the protein’s activity restored nuclear structure and the ability to divide in cells from aged non-human primates and animals modeling a premature-aging disorder.

Animal cell studyMechanisms

Paper

Cell Death DiscoveryNov 3

Protein loss increases bone loss in an animal model

Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.

Animal studyBones and joints

Paper

Cellular SignallingNov 1

Swimming exercise protects against diabetic cardiomyopathy through suppression of FABP4-associated CTRP3 degradation

Experiments in miceDiabetic cardiomyopathy

Paper

Cell Death & DiseaseOct 31

Virus-based delivery eased obesity or osteoporosis in mice

Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models.Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models.

Mouse studyOsteoporosis

Paper

Nature CommunicationsOct 30

Omaveloxolone eased age-related inflammation in male mice

Experiments in aged male mice found that the drug reduced inflammatory changes, likely through effects on both inflammatory and antioxidant pathways.Experiments in aged male mice found that the drug reduced inflammatory changes, likely through effects on both inflammatory and antioxidant pathways.

Mouse studyInterventions

Paper

Cell ProliferationOct 30

Purpurin reduced joint damage and osteoarthritis pain in mice

An animal experiment found that purpurin reduced degeneration of the meniscus, a knee cushion, in mice with surgically induced osteoarthritis.An animal experiment found that purpurin reduced degeneration of the meniscus, a knee cushion, in mice with surgically induced osteoarthritis.

Mouse studyOsteoarthritis

Paper

Advanced ScienceOct 26

In cells, senescent fat stem cells transfer damaged mitochondria

Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling…Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling in spinal disc cells.

Human cell studyCellular senescence

Paper

International Journal of Biological MacromoleculesOct 17

Pharmacological targeting of FKBPL with rapamycin sensitizes triple-negative breast cancer to ferroptosis

Experiments in cellsRapamycin

Paper

See all 130 papers on proteasomal degradation

Proteasomal degradation

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