pcaf-1

1. pcaf-1 activates daf-16 in worms.

   “Mechanistically, PCAF-1 drives DAF-16/FOXO activation”

   Model organisms

   Boosting a gene-regulating enzyme extended lifespan in worms

   bioRxiv·Nov 12, 2026Preprint

More on daf-16

1. pcaf-1 decreases protein aggregation in worms (models of human neurodegenerative diseases).

   “PCAF-1 strengthens inducible stress responses, attenuates the age-dependent decline in proteasomal degradation, and limits protein aggregation in C. elegans models of human neurodegenerative diseases”

   Model organismsmodels of human neurodegenerative diseases

   Boosting a gene-regulating enzyme extended lifespan in worms

   bioRxiv·Nov 12, 2026Preprint

1. pcaf-1 increases proteasomal degradation in worms during aging.

   “PCAF-1 strengthens inducible stress responses, attenuates the age-dependent decline in proteasomal degradation”

   Model organismsduring aging

   Boosting a gene-regulating enzyme extended lifespan in worms

   bioRxiv·Nov 12, 2026Preprint

1. pcaf-1 improves healthspan in worms (increased PCAF-1 dosage).

   “increasing the dosage of PCAF-1, the sole KAT2 family acetyltransferase in Caenorhabditis elegans, is sufficient to extend lifespan, preserve healthspan”

   Model organismsincreased PCAF-1 dosage

   Boosting a gene-regulating enzyme extended lifespan in worms

   bioRxiv·Nov 12, 2026Preprint

1. pcaf-1 extends lifespan in worms (increased PCAF-1 dosage).

   “increasing the dosage of PCAF-1, the sole KAT2 family acetyltransferase in Caenorhabditis elegans, is sufficient to extend lifespan”

   Model organismsincreased PCAF-1 dosage

   Boosting a gene-regulating enzyme extended lifespan in worms

   bioRxiv·Nov 12, 2026Preprint