Pharmacological Research
Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function
Experiments in miceInterventions
Papers on PPARα
171 papers11 new in 30 days
Monday, March 2
Wednesday, January 28
International Journal of Molecular Sciences
The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
ReviewCellular senescence
Saturday, January 24
Saturday, January 10
Monday, January 5
The American Journal of Pathology
Peroxisome Proliferator-Activated Receptor α Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy
Experiments in miceCellular senescence
Monday, December 29
Tuesday, December 23
AAIC 2025 Abstract
Chronic Type 2 Diabetes and Future Risks of Alzheimer’s Disease in Southeast Asian population
Cohort study of 18 peopleAlzheimer's disease
Thursday, December 18
International Journal of Pharmaceutics
Long-acting fenofibrate-loaded microparticles for treating retinal disorders
Experiments in animalsInterventions
Friday, December 5
Thursday, November 27
Friday, October 31
Molecular Medicine Reports
Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway
Experiments in miceRapamycin
Monday, October 27
Friday, October 24
Journal of Developmental Origins of Health and Disease
Early prenatal undernutrition leads to metabolic dysfunction-associated steatotic liver disease in a rat model of menopause
Experiments in animalsMechanisms
Monday, September 15
Research Square
A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans
Preprint: experiments in wormsReproductive system
Tuesday, August 12
bioRxiv
Nuclear Hormone Receptor NHR-49/HNF4α Couples Fertility Regulation to Resource Allocation and Longevity in C. elegans
Preprint: experiments in wormsReproductive system
Tuesday, July 29
Friday, June 13
Saturday, May 31
bioRxiv
SIRT1-IDR-Driven Temporal Gating of Sequential Transcription-Factor Recruitment Coordinates Fasting Adaptation
Preprint: experiments in miceSirtuin signaling
Tuesday, May 20
Nature Aging
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
Experiments in miceCellular senescence
Monday, April 21
Molecular Metabolism
Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study
Non-randomized trial in 20 peopleFasting
Sunday, April 20
Food Research International
Dietary emulsifier Polysorbate 80-induced lipotoxicity promotes intestinal senescence
Experiments in miceCellular senescence
Monday, March 10
Sunday, March 9
Trends in Endocrinology and Metabolism
Enhancer binding as a KEysTONE of fasting response
CommentaryMechanisms
Saturday, March 1
Poultry Science
Effects of induced molting on lipid accumulation in liver of aged laying hens
Experiments in chickensInterventions
Saturday, February 8
European Journal of Pharmacology
The diabetes medication Canagliflozin attenuates alcoholic liver disease by reducing hepatic lipid accumulation via SIRT1-AMPK-mTORC1 signaling pathway
Experiments in miceCanagliflozin
Tuesday, January 21
Saturday, December 21
Biochimica et Biophysica Acta Molecular Basis of Disease
Meteorin-like protein alleviates intervertebral disc degeneration by suppressing lipid accumulation in nucleus pulposus cells via PPARα-CPT1A activation
Experiments in ratsIntervertebral disc degeneration
Tuesday, December 3
European Journal of Pharmacology
Oxymatrine relieves non-alcoholic fatty liver disease by promoting sirtuin 1/adenosine 5'-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation
Experiments in ratsNon-alcoholic fatty liver disease