Chemico-biological Interactions
Fenofibrate induces liver enlargement in aging mice via activating the PPARα-YAP signaling pathway
Experiments in miceInterventions
Papers on PPARα
171 papers11 new in 30 days
Thursday, October 24
Monday, September 30
Monday, September 23
Tuesday, September 17
Advances in Experimental Medicine and Biology
Misalignment of Circadian Rhythms in Diet-Induced Obesity
ReviewMechanisms
Thursday, September 12
Monday, September 9
International Journal of Biological Sciences
Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy
Cohort study in peopleDietary restriction
Tuesday, September 3
Science China Life Sciences
Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model
Experiments in miceSGLT2 inhibitors
Saturday, August 31
Pharmacological Research
Omega-3 PUFAs slow organ aging through promoting energy metabolism
Experiments in miceOmega-3 fatty acids
Saturday, July 6
Saturday, June 29
Sunday, June 2
Biochimica et Biophysica Acta Molecular Basis of Disease
Aged microbiota exacerbates cardiac failure by PPARα/PGC1α pathway
Experiments in miceMicrobiome composition
Sunday, May 19
Phytomedicine
Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease
Experiments in miceSenolytics
Friday, March 29
Molecular Nutrition & Food Research
Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice
Experiments in 6 miceInterventions
Wednesday, March 27
NeuroImmune Pharmacology and Therapeutics
Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα
Experiments in miceInterventions
Saturday, December 23
Thursday, December 21
Wednesday, November 8
Nutrition & Diabetes
Fenofibrate alleviates insulin resistance by reducing tissue inflammation in obese ovariectomized mice
Experiments in miceInsulin resistance
Monday, September 4
Bioscience Trends
Influence of intermittent fasting on autophagy in the liver
ReviewIntermittent fasting
Friday, August 25
Tuesday, August 1
Molecular Metabolism
Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1
Experiments in miceFatty acid β-oxidation
Monday, June 12
American Journal of Translational Research
Moxibustion ameliorated age-related alterations in neurological behavior and gut microbiota in mice
Experiments in 30 miceGut and microbiome
Friday, April 21
The Journal of Nutritional Biochemistry
Resveratrol inhibits the formation and accumulation of lipid droplets through AdipoQ signal pathway and lipid metabolism lncRNAs
Experiments in 24 pigsResveratrol
Thursday, April 6
Acta Biochimica Polonica
Age-related effects of fenofibrate on the hepatic expression of sirtuin 1, sirtuin 3, and lipid metabolism-related genes
Experiments in 10 ratsInterventions
Friday, January 13
bioRxiv
IL-17 undermines longevity and stress tolerance by inhibiting a protective transcriptional network
Preprint: experiments in wormsMechanisms
Tuesday, November 22
International Journal of Endocrinology and Metabolism
The G-Protein-Coupled Estrogen Receptor Agonist Prevents Cardiac Lipid Accumulation by Stimulating Cardiac Peroxisome Proliferator-Activated Receptor α: A Preclinical Study in Ovariectomized-Diabetic Rat Model
Experiments in animalsInterventions
Saturday, October 29
Histology and Histopathology
Therapeutic roles of PPARα activation in ocular ischemic diseases
ReviewInterventions
Thursday, October 20
Wednesday, October 5
Free Radical Biology & Medicine
Regional heterogeneity in mitochondrial function underlies region specific vulnerability in human brain ageing: Implications for neurodegeneration
Cross-sectional study in peopleOxidative phosphorylation