Physiological age

Biomarker2 papers3 findings

  • Humans2

Associations

3

Inequalities in health

upin humans1

1 study
  1. Physiological age is associated with inequalities in health in humans.

    “We demonstrate physiological age as a powerful tool for revealing inequalities in health during ageing across national contexts.”

    Review

    PHYSIOLOGICAL AGING AND ITS USE AS A MARKER OF INEQUALITIES IN HEALTH: CROSS-NATIONAL PERSPECTIVES · GSA 2024 abstract · 31 Dec 2024

Education

downin humans1

1 study
  1. Education is associated with physiological age in humans.

    “women educated above high school level maintained PA younger than men at age 70.”

    Humansin women at age 70, educated above high schoolfemalesn = 8,891

    GENDER AND EDUCATIONAL DIFFERENCES IN TRAJECTORIES OF PHYSIOLOGICAL AGEING · GSA 2024 abstract · 31 Dec 2024

Female sex

upin humans1

1 study
  1. Female sex is associated with physiological age in humans (1.6 years (95% CI 1.0-2.1)).

    “by age 70, women had PA 1.6 years (95% confidence interval=1.0-2.1) older than men.”

    Humansby age 70femalesn = 8,891

    GENDER AND EDUCATIONAL DIFFERENCES IN TRAJECTORIES OF PHYSIOLOGICAL AGEING · GSA 2024 abstract · 31 Dec 2024

Latest

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NPJ AgingAnimals

Human protein variant eased signs of progeria in mice

An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median…An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.

Journal of Molecular and Cellular CardiologyAnimals

Persistent IFN-γ links to worse cardiac remodeling in aged mice

In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with…In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac remodeling.

GeroScienceHumans

Peak oxygen uptake falls in older cyclists over nine years

In 82 older cyclists followed across nine years, peak oxygen consumption fell 19.7%, dropping from 44.1 to 35.4 ml·kg⁻¹·min⁻¹.In 82 older cyclists followed across nine years, peak oxygen consumption fell 19.7%, dropping from 44.1 to 35.4 ml·kg⁻¹·min⁻¹.