Osteoclast formation

Papers on osteoclast formation

158 papers8 new in 30 days

Friday, November 13

bioRxiv

Bile acid reduced bone loss in mice with ovaries removed

In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.

A sturdy dark blue-green bone cross-section with dense struts and small cells sits beside a fragile gray bone with broken struts and a small mouse.
Preprint: mouse studyBone loss

Tuesday, November 3

Cell Death Discovery

Protein loss increases bone loss in an animal model

Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.

Figure from Cell Death Discovery
Animal studyBones and joints

Thursday, October 29

Cellular Signalling

Calcium pump may link force to bone-breakdown signals in cells

Experiments in lab-grown bone cells suggested that a calcium pump helps regulate signals promoting bone breakdown in response to fluid movement.Experiments in lab-grown bone cells suggested that a calcium pump helps regulate signals promoting bone breakdown in response to fluid movement.

Figure from Cellular Signalling
Animal cell studyBones and joints

Tuesday, October 27

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Wednesday, October 7

Nature Communications

Targeting a cell regulator reduced bone loss in mice

In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

Oxr1 is upregulated during osteoclast differentiation and osteoporosis pathogenesis.
Experiments in miceBones and joints

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