What does the research say about osteoclast formation?

Osteoclast formation

There are 12 papers on osteoclast formation in aging research: none in people yet, 11 in animals, 1 in cells. The newest story, Nov 3, 2026: “Protein loss increases bone loss in an animal model”.

Biomarker

12 papers study it146 more mention it1 finding

8 new papers in 30 daysSee all 158 papers on osteoclast formation

Animals11
Cells1

Upstream

AHR

upin mouse cells1

1 study

AHR increases osteoclast formation in mouse cells (shown by overexpression restoring IA-mediated inhibition of osteoclast formation).
“AhR acts as a key positive regulator in the process of osteoclastogenesis”
Cellsshown by overexpression restoring IA-mediated inhibition of osteoclast formation
Gut Metabolite Indoleacrylic Acid Suppresses Osteoclast Formation by AHR mediated NF-κB Signaling Pathway
International journal of biological sciencesJan 1, 2026

Latest

61 papers in 12 months

Cell Death DiscoveryNov 3

Protein loss increases bone loss in an animal model

Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.

Animal studyBones and joints

Paper

Research SquareAug 22

CIP2A promotes osteoclastogenesis and postmenopausal bone loss by activating a novel HMGA1–c-Myc–PI3K/AKT axis

Preprint: experiments in micePI3K–AKT signaling

Paper

Bioactive MaterialsApr 9

Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling

Experiments in miceBones and joints

Paper

bioRxivNov 13

Bile acid reduced bone loss in mice with ovaries removed

In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.

Preprint: mouse studyBone loss

Paper

PharmaceuticalsOct 29

Total Flavone of Flowers of Abelmoschus manihot (L.) Medic Suppress Nfatc1 Expression to Reduce Osteoclastogenesis Thereby Alleviating Ovariectomy-Induced Osteoporosis

Experiments in ratsOsteoporosis

Paper

Frontiers in PharmacologyOct 29

Esculin and esculetin protect against bone loss in osteoporosis by rebalancing osteoblast and osteoclast functions

Experiments in miceOsteoporosis

Paper

JBMR PlusOct 29

Niclosamide Suppresses Osteoclastogenesis and Bone Resorption: Involvement of STAT3 Signaling

Experiments in miceBones and joints

Paper

Cellular SignallingOct 29

Calcium pump may link force to bone-breakdown signals in cells

Experiments in lab-grown bone cells suggested that a calcium pump helps regulate signals promoting bone breakdown in response to fluid movement.Experiments in lab-grown bone cells suggested that a calcium pump helps regulate signals promoting bone breakdown in response to fluid movement.

Animal cell studyBones and joints