Osteoclasts
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41Targeting a cell regulator reduced bone loss in mice
In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.
Coated implants improved bone attachment in osteoporotic rats
A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.
Bone-targeting particles improved bone structure in mice
An experiment in mice whose ovaries had been removed found that engineered, bone-targeting particles also reduced pain-related behaviours.An experiment in mice whose ovaries had been removed found that engineered, bone-targeting particles also reduced pain-related behaviours.
Puerarin-loaded nanoparticles improve bone mass in mice
In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone…In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.
Bone-targeted exosomes delivering betaine reverse bone loss in osteoporotic rats
The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.
Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats
Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse…Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse model.