Alendronate
InterventionApproved 19953 papers2 findingsPubChem 2088ChEBI 2567
- Animals2
Outcomes
2CASP9
downin rats1Very low certainty
1 study
CASP9
downin rats1Very low certainty
Alendronate decreases CASP9 in rats.
Animalsovariectomyoral gavagefemur5 μg/kg/day10 weeksfemales
Comparison of Naringenin and Alendronate in the Attenuation of Ovariectomy-Induced Osteoporosis by Modulating Autophagy, Apoptosis, and Oxidative Stress in Rats · Iranian journal of pharmaceutical research : IJPR · 13 Jun 2026
Femoral stereological/histomorphometric outcomes
upin rats1Very low certainty
1 study
Femoral stereological/histomorphometric outcomes
upin rats1Very low certainty
Alendronate improves femoral stereological/histomorphometric outcomes in rats.
Animalsovariectomyoral gavagebone5 μg/kg/day10 weeksfemales
Comparison of Naringenin and Alendronate in the Attenuation of Ovariectomy-Induced Osteoporosis by Modulating Autophagy, Apoptosis, and Oxidative Stress in Rats · Iranian journal of pharmaceutical research : IJPR · 13 Jun 2026
Trials
75Approved
29 Sep 1995 · Osteoporosis, Paget's Disease of Bone, glucocorticoid-induced osteoporosis
17 Sep 2003 · Discontinued
12 Mar 2012 · Discontinued · Osteoporosis
Repurposing
Phase 4 · Completed · 1 trial
Phase 3 · Completed · 3 trials
Phase 4 · Completed · 5 trials
Phase 3 · Results posted · 1 trial
Phase 4 · Results posted · 10 trials
Phase 3 · Completed · 2 trials
All 26Fewer
Phase 4 · Completed · 1 trial
Phase 3 · Completed · 3 trials
Phase 4 · Completed · 1 trial
Phase 4 · Status unknown · 1 trial
Phase 3 · Results posted · 2 trials
Phase 3 · Results posted · 1 trial
Phase 4 · Completed · 1 trial
Phase 3 · Results posted · 3 trials
Phase 2/3 · Results posted · 1 trial
Phase 2 · Results posted · 1 trial
Phase 2 · Results posted · 2 trials
Phase 2 · Terminated · 1 trial
Phase 2/3 · Completed · 1 trial
Phase 2 · Results posted · 1 trial
Phase 2 · Completed · 1 trial
Phase 2 · Results posted · 1 trial
Phase 2/3 · Completed · 1 trial
Phase 2 · Recruiting · 1 trial
Phase 2 · Completed · 1 trial
Phase 1 · Completed · 1 trial
In trials
Metabolic bone disease
Phase 4 · Completed · 13 trials
Bone Resorption
Phase 4 · Completed · 3 trials
Osteonecrosis
Phase 4 · Status unknown · 2 trials
Primary hyperparathyroidism
Phase 4 · Completed · 1 trial
Breast Neoplasms
Phase 3 · Completed · 3 trials
Prostatic Neoplasms
Phase 3 · Completed · 3 trials
All 9Fewer
Rare Diseases
Phase 2 · Results posted · 2 trials
Spinal Cord Diseases
Phase 2 · Results posted · 2 trials
Central nervous system disease
Phase 2 · Results posted · 1 trial
Readouts due
- 26 Mar 2027
Small Trial of Alendronate Impact on the Reservoir of HIV
Phase 2 · Recruiting
Trial sponsors
Company12 trialsPhase 46,445 people
Company1 trialPhase 4341 people
Company1 trialPhase 4300 people
Company3 trialsPhase 3713 people
Company2 trialsPhase 34,343 people
Company1 trialPhase 31,139 people
Company2 trialsPhase 1222 people
Company1 trialPhase 1140 people