Papers on OASIS

141 papers10 new in 30 days

Wednesday, October 28

Preprints.orgOct 28

Defining and Predicting Inadequate Weight Response to Oral Semaglutide

Preprint: reviewSemaglutide

Paper

Monday, October 26

Cerebral CortexOct 26

Thickness of the brain’s outer layer is linked to cognitive aging

An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time.An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time.

Directed acyclic graph illustrating a structural equation model (SEM) testing dissociable pathways from age and polygenic score (PGS) to g via thickness and area.

Cohort studyMechanisms

Paper

Sunday, October 25

EClinicalMedicineOct 25

Elinzanetant’s safety profile appeared favorable in women

Over 12 weeks, new or worsening health problems occurred in 50.8% of women taking elinzanetant and 43.2% taking placebo.Over 12 weeks, new or worsening health problems occurred in 50.8% of women taking elinzanetant and 43.2% taking placebo.

Study design. aFor SWITCH-1, elinzanetant 40 mg, 80 mg, and 160 mg were excluded from the pooled safety analysis.

Meta-analysis · 1,519 peopleInterventions

Paper

Saturday, October 24

medRxivOct 24

Brain MRI score fell across Alzheimer’s disease stages

The score distinguished stable normal cognition from prediagnosis Alzheimer’s with an area under the curve—a measure of group separation—of 0.817.The score distinguished stable normal cognition from prediagnosis Alzheimer’s with an area under the curve—a measure of group separation—of 0.817.

Brain cross-sections show unevenly fanning nerve pathways in a large section beside more orderly, symmetrical pathways in a smaller section.

Preprint: cohort studyAlzheimer's disease

Paper

Monday, October 19

Journal of the National Cancer InstituteOct 19

Older breast cancer survivors may have unmet home-care needs

Among yearly records classified as high need, 59.6% showed no Medicare home-health use in an observational study of older breast cancer survivors.Among yearly records classified as high need, 59.6% showed no Medicare home-health use in an observational study of older breast cancer survivors.

Cohort · 134,410 peopleBiomarkers

Paper

Tuesday, October 13

Annals of Medicine and SurgeryOct 13

Advances in pharmacologic management of obesity: oral semaglutide for weight management

ReviewSemaglutide

Paper

Tuesday, October 6

arXivOct 6

Riemannian Shape Analysis of the Corpus Callosum in Kendall Space: Aging and Alzheimer's Disease

Preprint: cross-sectional study of 252 peopleAlzheimer's disease

Paper

Friday, October 2

medRxivOct 2

AI model predicts Alzheimer's conversion across cohorts

In 101 people with mild cognitive impairment, the model predicted conversion with an AUC of 0.72 and mirrored rates of brain atrophy and cognitive decline.In 101 people with mild cognitive impairment, the model predicted conversion with an AUC of 0.72 and mirrored rates of brain atrophy and cognitive decline.

Higher TAF-Net risk tracks faster medial-temporal atrophy Spearman rank correlations between TAF-Net risk and regional annualised atrophy rate (SPC/yr); n = 41.

Preprint: computational studyAlzheimer's disease

Paper

medRxivOct 2

Automated tool counts teeth from routine brain MRI

The model counted teeth with a mean absolute error of 1.96 and matched manual associations with cognitive scores in a 233-person cohort.The model counted teeth with a mean absolute error of 1.96 and matched manual associations with cognitive scores in a 233-person cohort.

Bite-box extraction from whole-head T1w MRI.

Preprint: computational studyAI & data

Paper

Thursday, October 1

Journal of Mechanics in Medicine and BiologyOct 1

SCREENING OF COGNITIVE IMPAIRMENT BIOMARKERS BASED ON MACHINE LEARNING AND SHAP INTERPRETABILITY ANALYSIS

Study in peopleBiomarkers

Paper

Saturday, September 26

Journal of Clinical EpidemiologySep 26

Factor-specific decomposition of mortality predictions produced individualized profiles that varied by population and prediction horizon

Cohort study of 50,917 peopleBiomarkers

Paper

Thursday, September 17

Research SquareSep 17

Added prognostic value of a laboratory frailty index for hospital mortality in surgical intensive care: a two-database cohort study

Preprint: cohort study of 16,101 peopleBiomarkers

Paper

Monday, September 14

MathematicsSep 14

Leakage-Aware Explainable Alzheimer’s Disease Detection Using Ensemble-Based Tree Models and Shapley Additive Explanations

Computational studyBiomarkers

Paper

Thursday, September 10

Research SquareSep 10

How Reliable and Explainable Are Machine Learning Models for Dementia Detection? A Leakage-Aware Evaluation

Preprint: computational studyDementia

Paper

Tuesday, September 8

Obesity Science & PracticeSep 8

A Systematic Review and Meta-Analysis of Malnutrition and Metabolic Failure in High-Potency Incretin Therapy

PRISMA 2020 Flow Diagram of Study Selection and Attrition.

Meta-analysis of randomized trialsMalnutrition

Paper

Monday, September 7

arXivSep 7

Modeling Brain MRI Using Persistent Homology and Multilevel Functional Data Analysis

Preprint: computational studyBiomarkers

Paper

Friday, September 4

arXivSep 4

A Generalizable Feature Extractor for Alzheimer's-Related Brain MRI Tasks

Preprint: computational studyAI & data

Paper

Monday, August 31

arXivAug 31

Benchmarking External Generalization of SPD Matrix Learning for Resting-State fMRI Connectome Prediction

Preprint: computational studyDeep learning

Paper

Thursday, August 27

PharmaceuticalsAug 27

Oral vs. Subcutaneous Semaglutide for Obesity Treatment: A Systematic Review of Efficacy, Safety, and Patient-Oriented Outcomes

PRISMA 2020 flow diagram of study selection.

Systematic review of studies in peopleSemaglutide

Paper

Sunday, August 9

The Journal of Prevention of Alzheimer's DiseaseAug 9

Quantifying generalization error in machine learning prediction of cognitive decline

Computational studyBiomarkers

Paper

Wednesday, August 5

Journal of Alzheimer's DiseaseAug 5

Beyond binary classification: A tiered claims-based algorithm for Alzheimer's disease and related dementias in Medicare

Cohort study in peopleAlzheimer's disease and related dementias

Paper

Tuesday, August 4

arXivAug 4

When Is a Conformal Guarantee Fair? Auditing Silent Subgroup Under-Coverage in Alzheimer's Disease Longitudinal Prediction

Preprint: computational studyAlzheimer's disease

Paper

Saturday, August 1

MaturitasAug 1

Consistency of efficacy and safety of elinzanetant for vasomotor symptoms and sleep disturbance associated with menopause across different populations: a review of the OASIS clinical trial program

ReviewVasomotor symptoms

Paper

Tuesday, July 28

SleepJul 28

Elinzanetant in postmenopausal women with sleep disturbance: results from the randomized, phase II NIRVANA study

Trial in peopleInterventions

Paper

Women's HealthJul 28

Podcast: Patient voices and clinical advances-Elinzanetant for menopause symptom management associated with breast cancer treatment in the OASIS-4 trial

ReviewInterventions

Paper

Thursday, July 16

medRxivJul 16

Sex and gene variant linked to brain aging mainly with amyloid

An observational study of 1,337 people found these links primarily among participants positive for amyloid, a protein that can build up in the brain.An observational study of 1,337 people found these links primarily among participants positive for amyloid, a protein that can build up in the brain.

Preprint: cohort · 1,337 peopleBiomarkers