Nucleotide pools
2 papers1 finding
- Animals2
Interventions
1Dehydroepiandrosterone
no changein mice1
1 study
Dehydroepiandrosterone
no changein mice1
Dehydroepiandrosterone has no effect on nucleotide pools in mice (did not deplete).
“treatment with DHEA did not deplete cellular nucleotide pools in the liver, as would have been predicted”
Animalsin p53-deficient miceliver0.3% of the diet
CarcinogenesisMay 1, 1997
Latest
Free Radical Biology & Medicine
8-Oxoguanine modifications in peripheral leukocyte microRNAs promote age-related inflammation by remodeling gene regulatory networks
Cohort study in peopleInflammation
Developmental Cell
Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate
Experiments in killifishInterventions
Journal of Biochemistry
Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication
Experiments in cellsInterventions
Molecular Cell
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
Experiments in cellsMechanisms
Trends in Biochemical Sciences
Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer
ReviewMechanisms
The Journal of Biological Chemistry
Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances
Experiments in miceInterventions