16alpha-fluoro-5-androsten-17-one

16alpha-fluoro-5-androsten-17-one extends lifespan in mice (to 140 days, P = 0.037).

“Treatment with a synthetic DHEA analog, 16alpha-fluoro-5-androsten-17-one (compound 8354), at 0.15% of the diet also increased lifespan, to 140 days for mice that developed tumors (P = 0.037).”

Animalsin p53-deficient mice that developed tumorsdiet0.15% of the diet

Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16alpha-fluoro-5-androsten-17-one

Carcinogenesis·May 1, 1997