Molecular Biomedicine
Dietary fat rebalanced brain membrane fats in mice
Docosahexaenoic acid restored brain energy function in six- and 12-month dietary experiments in female mice carrying a human gene variant linked to Alzheimer’s disease.Docosahexaenoic acid restored brain energy function in six- and 12-month dietary experiments in female mice carrying a human gene variant linked to Alzheimer’s disease.
Experiments in 37 female ApoE3/3 and ApoE4/4 knock-in mice, against control-diet ApoE4/4 miceInterventions
Limit: Lipidomics sampled cerebellum, not cortex or hippocampus, limiting claims about brain-wide membrane rebalancing