Journal of Leukocyte Biology·Oct 25Spermidine-mediated AMPK signaling pathway drives M2 macrophage polarization to promote the growth of vaginal cancerExperiments in cellsAMPK signalingPaper
Iranian Journal of Basic Medical Sciences·Jun 15Protective effects and mechanism of chrysophanol against age-related osteoporosis in ratsExperiments in ratsOsteoporosisPaper
Biomolecules & Therapeutics·Apr 30Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR AxisExperiments in ratsChronic obstructive pulmonary diseasePaper
bioRxiv·Mar 30Canonical mTOR signaling supports complete fin regenerationPreprint: experiments in animalsType I interferon signalingPaper
Aging·Nov 21On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. BlagosklonnyCommentaryMechanismsPaper
Food Research International·Aug 12Corn-derived peptide LQQQLL alleviates skeletal muscle attenuation by mTOR signaling pathway and intestinal microbiotaExperiments in miceMusclePaper
bioRxiv·Mar 28Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescencePreprint: experiments in miceInterventionsPaper
Pharmacological Reports·Aug 19Fast-acting antidepressant-like effects of ketamine in aged male ratsExperiments in ratsInterventionsPaper
Sheng Li Xue Bao·Jun 28Effects of different exercise modes on neuromuscular junction and metabolism of skeletal muscle-related proteins in aging ratsExperiments in 38 ratsEndurance exercisePaper
Acta Biochimica et Biophysica Sinica·May 28Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagyExperiments in ratsKidneyPaper
BMC Neurology·Apr 5Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocolStudy protocolRapamycinPaper
medRxiv·Feb 20Evaluating the effect of rapamycin treatment in Alzheimer's Disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocolPreprint: study protocolRapamycinPaper
Nutrients·Jan 22Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on SarcopeniaExperiments in miceSarcopeniaPaper
International Journal of Molecular Sciences·Nov 12Coapplication of Magnesium Supplementation and Vibration Modulate Macrophage Polarization to Attenuate Sarcopenic Muscle Atrophy through PI3K/Akt/mTOR Signaling PathwayExperiments in miceMagnesiumPaper
Biochemical Pharmacology·Oct 2Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-SyndromeExperiments in miceRapamycinPaper
Zhen Ci Yan Jiu·Feb 8Effect of electroacupuncture on hepatocyte autophagy and oxidative stress in SAMP8 mice by regulating AMPK/mTOR/ULK1 signaling pathwayExperiments in 24 miceInterventionsPaper
GeroScience·Jan 12SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndromeExperiments in human cellsInterferon-γ signalingPaper
Scientific Reports·May 20Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageingExperiments in miceMusclePaper
Developmental Cell·Apr 18HLH-30/TFEB Is a Master Regulator of Reproductive QuiescenceExperiments in wormsMechanismsPaper
Poultry Science·Apr 4Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of rapamycin pathwayExperiments in 60 chickensMelatoninPaper
Food & Nutrition Research·Feb 23Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male miceExperiments in 36 miceDietary restrictionPaper
Journal of Medical Systems·Jul 6Basic Research in Diabetic Nephropathy Health Care: A study of the Renoprotective Mechanism of MetforminExperiments in miceMetforminPaper
Toxicology in Vitro·Mar 21Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cellsExperiments in mouse cellsAutophagyPaper
Clinical Epigenetics·Jan 27The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort studyCohort study of 1,000 peopleCancerPaper
Advances in Gerontology·Jan 1Geroprotective drugs - mTOR inhibitors in the treatment of cancer patientsReviewmTOR inhibitorsPaper
Advances in Experimental Medicine and Biology·Nov 6mTOR Signaling Pathway and Protein Synthesis: From Training to Aging and Muscle AutophagyReviewmTOR signalingPaper
Science Translational Medicine·Jul 13TORC1 inhibition enhances immune function and reduces infections in the elderlyRandomized trial in 264 peopleInfectionPaper
Scientific Reports·Jan 12Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycinExperiments in micemTOR signalingPaper
PNAS·Oct 29Twenty-five years of mTOR: Uncovering the link from nutrients to growthReviewmTOR signalingPaper
Nutrition·May 21Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levelsExperiments in miceCoffeePaper