Mitochondrial DNA release

1 paper2 findings

Model organisms1

Effects

2

Cognitive function

downin reviews1

1 study

Mitochondrial DNA release impairs cognitive function.
“highlights the mitochondria-immune axis as a central contributor to neurodegeneration and cognitive decline”
Review
Linking mitochondrial DNA release to neurodegeneration and cognitive decline
Ageing research reviews21 Feb 2026

Immune response

upin reviews1

1 study

Mitochondrial DNA release activates immune response.
“mtDNA can act as a damage-associated molecular pattern when released from mitochondria, triggering innate immune signaling pathways in the nervous system.”
Review
Linking mitochondrial DNA release to neurodegeneration and cognitive decline
Ageing research reviews21 Feb 2026

More on Immune response

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PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence

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Peroxiredoxin 6 limits mitochondrial peroxidation to prevent mitochondrial ER contact site assembly and inflammatory signalling following adaptive stress

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International Journal of Molecular Sciences12 Jun

Sex Differences in Mitochondrial Function: Endocrine Regulation, Immunometabolic Signaling, and Implications for Health and Disease

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Biology of Reproduction11 May

O-GlcNAcylation of p66Shc drives senescence-associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†

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Ageing Research Reviews24 Feb

Linking mitochondrial DNA release to neurodegeneration and cognitive decline

ReviewMitochondrion

Aging Cell19 Jan

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK-ULK1-Mediated Mitochondrial Quality Control

Experiments in miceInterventions

Journal of Neuroinflammation3 Apr

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling

Experiments in animalsInterventions