Microglial activation
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23Protein deficiency impaired memory in aging mice
Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell…Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signalling and increased activity linked to inflammation.
Silencing LCN2 eases postoperative cognitive deficits in mice
AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.
TRPM3 inhibition reverses depressive behaviors in rats
In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.
Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in…Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice
The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
Microglial ALKBH5 loss protects fat browning in aging male mice
Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.Knocking out the RNA demethylase ALKBH5 in microglia enhanced sympathetic innervation and preserved subcutaneous brown adipocytes in aging male mice.