Mesenchymal stem cells

Biomarker

1 paper1 finding

  • Animals1

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Bone marrow aging

upin mice1

1 study
  1. Bone marrow aging increases mesenchymal stem cells in mice.

    “In the aged bone marrow, the content of mesenchymal stem cells (BMSCs) and macrophages (BMMs) significantly increases.”

    Animalsbone marrow

    Single-cell RNA sequencing analysis combined with bulk RNA sequencing revealed changes in the micro-environment of bone marrow aging

    The journals of gerontology. Series A, Biological sciences and medical sciences21 Nov 2025

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Pharmaceutical Biology

Honokiol promotes bone formation and fracture repair in mice

In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the…In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the enzyme.

Experiments in miceBones and joints
Advanced Science

Lamin B1 deficiency impairs bone formation in stem cells

In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.

Experiments in cellsBones and joints
Stem Cell Research & Therapy

Particles from modified stem cells improve mouse heart function

In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.

Experiments in miceInterventions