FAP

5 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

3 independent labs in 2 countries

Funders: Medical Science and Technology Project of Zhejiang Province and 2 more

Animals3
Cells1

Interventions

Metformin

downin human cells1

1 study

Metformin decreases FAP in human cells.
“FAP-α expression increased in senescent fibroblasts (91.83 ± 4.36 vs. 78.17 ± 2.56 in controls, p < 0.05) and declined towards baseline with metformin treatment, being significantly reduced at 5 and 10 mM.”
Cellsin H2O2-induced senescent fibroblasts5 and 10 mM
Metformin promotes wound healing in senescent fibroblasts by regulating SIRT1 and FAP-α
Histochemistry and cell biology6 Nov 2025

Effects

CD274

upin mouse cells1

1 study

FAP increases CD274 in mouse cells.
“FAPα stabilized PD-L1 expression by maintaining its N-glycosylation and inhibiting proteasomal degradation”
Cells
FAPα⁺ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD-L1 and T Cell Senescence
Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Jan 2026

Associations

NPPB

upin silico1

1 study

FAP is associated with NPPB in silico.
“In silico mapping and proteolytic assays identified NPPB as an FAP substrate.”
In silicoin silico mapping and proteolytic assays
The role of fibroblast activation protein on left ventricular growth and matrix signaling as a function of age
AHA Scientific Sessions 2025 abstract3 Nov 2025