Papers on LINE1
31 papers
Wednesday, August 26
Monday, June 29
Research Square
Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance
Preprint: experiments in human cellsCellular senescence
Tuesday, March 3
Nucleic Acids Research
DAXX governs the silencing of LINE1 during spermatogenesis in mice
Experiments in miceMechanisms
Thursday, February 12
bioRxiv
Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations
Preprint: experiments in miceDNA repair
Tuesday, January 6
Cellular Signalling
Nuclear SIRT6 depletion activates LINE1-cGAS-STING pathway to induce PASMCs senescence in hypoxic pulmonary hypertension
Experiments in animalscGAS–STING signaling
Monday, November 17
Monday, July 21
Monday, May 26
Bioinformatics and Biology Insights
Structural Insights Into centSIRT6: Bioinformatic Analysis of N308K and A313S Substitution Effects
Computational studyMechanisms
Wednesday, April 2
Saturday, February 22
Alzheimer's & Dementia
Human herpesvirus-associated transposable element activation in human aging brains with Alzheimer's disease
Cohort study in peopleAlzheimer's disease
Wednesday, January 29
Mechanisms of Ageing and Development
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation
Experiments in human cellsInterventions
Tuesday, December 17
Foods
In Vivo and In Vitro Studies Assessing the Safety of Monosodium Glutamate
Experiments in fliesInterventions
Wednesday, November 13
Advances in Gerontology
Epigenetic mechanisms of the interrelations of osteoarthritis with aging
ReviewBones and joints
Thursday, October 17
bioRxiv
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project
Preprint: study of 864 dogsDNA methylation
bioRxiv
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation
Preprint: experiments in miceTransposable element activity
Wednesday, October 9
Science Advances
LINE1 modulate human T cell function by regulating protein synthesis during the life span
Study in peopleTransposable element activity
Monday, July 29
Thursday, June 13
EMBO Reports
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence
Experiments in human cellsTransposable element activity
Tuesday, May 2
Cell Discovery
Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells
Experiments in mouse cellsTransposable element activity
Monday, December 12
Wednesday, November 2
International Journal of Radiation Biology
The effects of transpositions of functional I retrotransposons depend on the conditions and dose of parental exposure
Experiments in fliesTransposable element activity
Tuesday, October 11
The EMBO Journal
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Genetic association study of 550 peopleSIRT6
Friday, October 7
Tuesday, March 29
Vavilovskii Zhurnal Genetiki I Selektsii
The relationship of lamins with epigenetic factors during aging
ReviewMechanisms
Tuesday, March 15
Nucleic Acids Research
BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates
Experiments in monkeysCellular senescence
Saturday, April 10
Frontiers in Cell and Developmental Biology
Tet1 Deficiency Leads to Premature Ovarian Failure
Experiments in miceReproductive system
Thursday, July 2
Aging Cell
Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Cross-sectional study in peopleDNA methylation
Sunday, June 7
Protein & Cell
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Experiments in human cellsMechanisms
Tuesday, July 2
Aging Cell
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes
Case-control study in peopleMechanisms
Thursday, March 7
Cell Metabolism
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Experiments in miceInflammation