Labile iron pool

4 papers3 findings

Animals1
Cells2

Upstream

1

GM5532

upin mouse cells1

1 study

GM5532 increases labile iron pool in mouse cells.
“This cascade reduces the intracellular labile iron pool.”
Cellsshown by Gm5532 KO
LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2
Cell biology and toxicology4 Feb 2026

Associations

2

Mitochondrial DNA damage

upin humans1

1 study

Labile iron pool is associated with mitochondrial DNA damage in humans.
“This accumulation is associated with an altered expression of mitochondrial quality control (MQC) markers and increased mitochondrial DNA damage”
Reviewreduced physical performanceskeletal muscle
Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control
Cells3 May 2025

More on Mitochondrial DNA damage

Reduced physical performance

upin humans1

1 study

Reduced physical performance is associated with labile iron pool in humans.
“In older adults with reduced physical performance, an increase in the labile iron pool within skeletal muscle is observed.”
Reviewreduced physical performanceskeletal muscle
Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control
Cells3 May 2025

Latest

1 in 12 months

Cell Biology and Toxicology4 Feb

LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2

Experiments in miceNRF2–KEAP1 antioxidant response

Nature Aging18 Oct

Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation

Experiments in miceIron

Cells13 May

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control

ReviewMitochondrion

Glia19 Mar

Fibroblasts and hiPS-Derived Astrocytes From CoPAN Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype

Experiments in cellsMechanisms

Journal of Proteome Research18 Jul

Taurine Alleviates Ferroptosis-Induced Metabolic Impairments in C2C12 Myoblasts by Stabilizing the Labile Iron Pool and Improving Redox Homeostasis

Experiments in cellsInterventions

Current Medicinal Chemistry14 Feb

Modulation of the HIF-1α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-hepatic Fibrosis Mechanism of Curcumol

Experiments in human cellsLiver fibrosis

Redox Biology5 Jan

Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

Experiments in cellsInterventions