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4,4'-dimethoxychalcone

Intervention

4 papers14 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 3 independent labs in 4 countries
  • Funders: Agence Nationale de la Recherche and others
  • 5 of 13 findings with company ties
  • Animals2
  • Cells1

Outcomes

10

Lifespan

upin flies1upin model organisms1upin reviews1upin worms1+1

3 studies

  1. 4,4'-dimethoxychalcone extends lifespan.

    “4,4'-dimethoxychalcone was the first chalcone to be shown to mediate geroprotection and lifespan extension across different species.”

    Review

    The geroprotective potential of chalcones

    Nature communications15 Oct 2025

  2. 4,4'-dimethoxychalcone extends lifespan.

    “4,4'-dimethoxychalcone (DMC), which promotes longevity in yeast, worms and flies”

    Model organisms

    4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

    Autophagy28 Jun 2019

  3. 4,4'-dimethoxychalcone extends lifespan in flies.

    “External DMC administration extends the lifespan of yeast, worms and flies”

    Model organisms

    The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species

    Nature communications19 Feb 2019

  4. 4,4'-dimethoxychalcone extends lifespan in worms.

    “External DMC administration extends the lifespan of yeast, worms and flies”

    Model organisms

    The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species

    Nature communications19 Feb 2019

  5. 4,4'-dimethoxychalcone extends lifespan in yeast cells.

    “External DMC administration extends the lifespan of yeast, worms and flies”

    Cells

    The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species

    Nature communications19 Feb 2019

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

  1. 4,4'-dimethoxychalcone decreases senescence-associated secretory phenotype (SASP) in mice.

    “reduced the expression of several senescence-associated secretory phenotype factors (IL-6, IL-1β, CXCL-10, and MMP12) in the liver of old mice”

    Animalsagingliver

    Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

    Redox biology30 Dec 2023

More on Senescence-associated secretory phenotype (SASP)

Hair loss

downin mice1

1 study

  1. 4,4'-dimethoxychalcone prevents hair loss in mice.

    “DMC treatment prevented hair loss”

    Animalsaging

    Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

    Redox biology30 Dec 2023

Motor coordination

upin mice1

1 study

  1. 4,4'-dimethoxychalcone improves motor coordination in mice.

    “DMC treatment prevented hair loss, improved motor coordination”

    Animalsaging

    Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

    Redox biology30 Dec 2023

Senescent cells

downin mouse cells1

1 study

  1. 4,4'-dimethoxychalcone decreases senescent cells in mouse cells.

    “DMC treatment selectively eliminated senescent cells”

    Cellssenescent cells

    Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

    Redox biology30 Dec 2023

More on Senescent cells

Autophagy

upin cells1

1 study

  1. 4,4'-dimethoxychalcone induces autophagy in cells.

    “DMC induces autophagy by inhibiting specific GATA transcription factors (TFs), independently of the TORC1 kinase pathway”

    Cells

    4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

    Autophagy28 Jun 2019

More on Autophagy

Liver toxicity

downin animals1

1 study

  1. 4,4'-dimethoxychalcone protects against liver toxicity.

    “protects mice from heart injury and liver toxicity”

    Animalsliver

    4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

    Autophagy28 Jun 2019

Heart injury

downin animals1

1 study

  1. 4,4'-dimethoxychalcone protects against heart injury.

    “protects mice from heart injury and liver toxicity”

    Animalsheart

    4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

    Autophagy28 Jun 2019

Myocardial ischemia

downin mice1

1 study

  1. 4,4'-dimethoxychalcone protects against myocardial ischemia in mice.

    “protects mice from prolonged myocardial ischaemia”

    Animalsprolonged myocardial ischaemiaheart

    The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species

    Nature communications19 Feb 2019

More on Myocardial ischemia

Cellular senescence

downin human cells1

1 study

  1. 4,4'-dimethoxychalcone decreases cellular senescence in human cells.

    “decelerates senescence of human cell cultures”

    Cells

    The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species

    Nature communications19 Feb 2019

More on Cellular senescence

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