Kynurenine
Biomarker4 papers2 findings
- Human trial1
- Humans1
- Animals1
- Cells1
Interventions
1TLN-01
upin humans1Moderate certainty
1 study
TLN-01
upin humans1Moderate certainty
TLN-01 increases kynurenine in humans.
Human trialsarcopenia8 weeksn = 34
Effects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial · Life (Basel, Switzerland) · 14 Aug 2026
Associations
1Low physical resilience
upin humans1
1 study
Low physical resilience
upin humans1
Low physical resilience is associated with kynurenine in humans.
“Kynurenine, a tryptophan metabolite linked to age-related functional decline, increased more steeply with age in individuals with low physical resilience.”
Humansserum
Serum metabolomics reveals signatures associated with physical resilience trajectories from middle to older age · bioRxiv · 21 Sep 2026 · Preprint
Funding
National Institute on AgingUS$2.9m3 grants since 2011
Kynurenine accumulation drives loss of muscle and bone function with aging
National Institute on AgingAugusta UniversityUS$2.3m2011–2027
National Institute on AgingJohns Hopkins UniversityUS$130.1k2022–2027
Linking kynurenine accumulation and the AHR pathway to exacerbated aging
National Institute on AgingUniversity of FloridaUS$472.4k2022–2027