Kynurenine/tryptophan ratio

1. Emtricitabine increases kynurenine/tryptophan ratio in mice.

   “Short-term FTC treatment increased serum KYN:tryptophan ratio and activated AhR signaling in skeletal muscle of Tg26 mice”

   Animalsin Tg26 miceserumfemales

   The antiretroviral drug emtricitabine increases kynurenine: tryptophan ratio, aryl hydrocarbon receptor activation, and cellular senescence in female mice

   Biochimie·28 Dec 2025

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1. Sarcopenia is associated with kynurenine/tryptophan ratio in humans.

   “serum KYN concentrations and the KYN/Trp ratio were significantly higher in the SG group than in the NSG group (p = 0.011 and p = 0.043, respectively)”

   Humansadjusted for age and BMI

   Gut microbial characteristics and kynurenine-related metabolism across sarcopenia groups: associations with neuromuscular and physical function

   Frontiers in aging neuroscience·25 Sep 2026

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