Laparotomy

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals1

Outcomes

Quinolinic acid to kynurenine ratio

downin mice1

1 study

Laparotomy decreases quinolinic acid to kynurenine ratio in mice.
“The quinolinic acid: kynurenine ratio decreased in aged surgery mice, indicating altered pathway flux.”
Animals48 h
Subclinical Hepatic Injury and Dysfunction Following Surgery: Evidence From a Young and Aged Laparotomy Murine Model
FASEB journal : official publication of the Federation of American Societies for Experimental Biology22 Dec 2025

More on Quinolinic acid to kynurenine ratio

Quinolinic acid

upin mice1

1 study

Laparotomy increases quinolinic acid in mice (+24% p < 0.001).
“with a similar age-dependent quinolinic acid elevation (+24% p < 0.001).”
Animals48 h
Subclinical Hepatic Injury and Dysfunction Following Surgery: Evidence From a Young and Aged Laparotomy Murine Model
FASEB journal : official publication of the Federation of American Societies for Experimental Biology22 Dec 2025

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FASEB Journal22 Dec

Subclinical Hepatic Injury and Dysfunction Following Surgery: Evidence From a Young and Aged Laparotomy Murine Model

Experiments in miceMechanisms

Paper

Laparotomy

Outcomes

Latest

Subclinical Hepatic Injury and Dysfunction Following Surgery: Evidence From a Young and Aged Laparotomy Murine Model

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