Kansas City Cardiomyopathy Questionnaire Overall Summary score

1. Transcatheter edge-to-edge repair is linked with better Kansas City Cardiomyopathy Questionnaire Overall Summary score in humans (primary mitral regurgitation) (improved significantly).

   “Functional status and Kansas City Cardiomyopathy Questionnaire - Overall Score improved significantly across age groups, without differences according to age.”

   Humansprimary mitral regurgitation1 year

   Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly

   Journal of the American Heart Association·Mar 18, 2026

More on Transcatheter edge-to-edge repair

1. Dapagliflozin improves Kansas City Cardiomyopathy Questionnaire Overall Summary score in humans (FI class 3 (most frail)) (3.4, 95% CI 1.7-5.1).

   “placebo-corrected improvement in Kansas City Cardiomyopathy Questionnaire Overall Summary Score at 4 months in FI class 1 was 0.3 (95% CI, -0.9 to 1.4); in class 2, 1.5 (0.3-2.7); and in class 3, 3.4 (1.7-5.1; Pinteraction=0.021)”

   Human trialFI class 3 (most frail)4 months

   Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial

   Circulation·Aug 27, 2022

More on Dapagliflozin

1. Left ventricular end-diastolic pressure is associated with Kansas City Cardiomyopathy Questionnaire Overall Summary score in patients with elevated LVEDP (>18 mm Hg) (26.5% <80, mean 85 ± 20).

   “Of 653 KCCQ-OS scores collected (mean 85 ± 20), 31.4% had a KCCQ-OS of 100 (asymptomatic), and 26.5% had a KCCQ-OS <80, consistent with NYHA functional class II-IV.”

   Humansin patients with elevated LVEDP (>18 mm Hg)n = 653

   Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure

   JACC. Advances·Jul 18, 2025

More on Left ventricular end-diastolic pressure