Transcatheter edge-to-edge repair

1. Transcatheter edge-to-edge repair is linked with better Kansas City Cardiomyopathy Questionnaire Overall Summary score in humans (primary mitral regurgitation) (improved significantly).

   “Functional status and Kansas City Cardiomyopathy Questionnaire - Overall Score improved significantly across age groups, without differences according to age.”

   Humansprimary mitral regurgitation1 year

   Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly

   Journal of the American Heart Association·Mar 18, 2026

More on Kansas City Cardiomyopathy Questionnaire Overall Summary score

1. Transcatheter edge-to-edge repair is linked with lower left ventricular end-diastolic volume in humans (primary mitral regurgitation) (-12.0±28.8 mL, P=0.003).

   “LV end-diastolic volumes improved to similar extent (-12.0±28.8 mL, P=0.003 and -14.1±31.5 mL, P<0.0001, P=0.34 across groups).”

   Humansprimary mitral regurgitation1 year

   Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly

   Journal of the American Heart Association·Mar 18, 2026

More on Left ventricular end-diastolic volume

1. Transcatheter edge-to-edge repair is linked with lower mortality in humans (43.2% versus 69.5%).

   “The 1-year mortality rate in the MCS-assisted M-TEER group was lower than the estimated mortality rate in the virtual control group (43.2% versus 69.5%).”

   Humansin critically ill patients with significant mitral regurgitation and unstable hemodynamics requiring MCSn = 105

   Safety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: The OCEAN-Mitral Registry

   Journal of the American Heart Association·Dec 10, 2025

1. Transcatheter edge-to-edge repair is linked with better handgrip strength in secondary MR with successful MR reduction (MR ≤2+).

   “Conversely, in secondary MR, it significantly increased in those with successful MR reduction”

   Humansin secondary MR with successful MR reduction (MR ≤2+)1 year

   Handgrip strength as a marker of frailty in patients with transcatheter edge-to-edge repair: Insights from the OCEAN-mitral registry

   International journal of cardiology·Nov 19, 2024

More on Handgrip strength

1. Transcatheter edge-to-edge repair is linked with a lower risk of mortality in humans (moderate or severe AFMR) (HR 0.58, 95% CI 0.35-0.99).

   “secondary endpoints (HR 0.58, 95% CI 0.35-0.99, P = .044).”

   Humansmoderate or severe AFMRn = 1,081

   Transcatheter edge-to-edge repair vs medical therapy in atrial functional mitral regurgitation: a propensity score-based comparison from the OCEAN-Mitral and REVEAL-AFMR registries

   European heart journal·Jul 9, 2025

1. Transcatheter edge-to-edge repair is linked with a lower risk of composite of all-cause mortality and heart failure hospitalization in humans (moderate or severe AFMR) (HR 0.65, 95% CI 0.43-0.99).

   “TEER was associated with a lower incidence of the primary (hazard ratio [HR] 0.65, 95% confidence interval [CI] 0.43-0.99, P = .044)”

   Humansmoderate or severe AFMRn = 1,081

   Transcatheter edge-to-edge repair vs medical therapy in atrial functional mitral regurgitation: a propensity score-based comparison from the OCEAN-Mitral and REVEAL-AFMR registries

   European heart journal·Jul 9, 2025