Left ventricular end-diastolic pressure
There are 13 papers on left ventricular end-diastolic pressure in aging research: 2 observational studies in people, 10 in animals, 1 review.
13 papers study it4 more mention it6 findings
1 new paper in 30 daysSee all 17
“Among 2,040 screened patients (mean age 74 ± 8 years; 49.8% women; 64.6% with diabetes mellitus; and 34.9% with CKD), 38.5% had an elevated LVEDP.”
- Humans2
- Animals10
Interventions
3Semaglutide
downin pigs1−62%
1 study
Semaglutide
downin pigs1−62%
Semaglutide decreases left ventricular end-diastolic pressure in pigs (DOCA and high-fat Western diet-induced HFpEF) (-62%).
“decreased LVEDP by 62% along with a similar reduction in PCWP”
AnimalsDOCA and high-fat Western diet-induced HFpEF8 nmol/kg, IM, once weekly12 weeksfemalesn = 5
AHA Scientific Sessions 2025 abstract
Blood flow restriction + exercise
downin rats1
1 study
Blood flow restriction + exercise
downin rats1
Blood flow restriction + exercise decreases left ventricular end-diastolic pressure in rats (aging) (P < 0.05 and P < 0.01).
“BFR + Ex displayed significantly lower LVEDP (P < 0.05 and P < 0.01 vs. Ex, and other groups, respectively)”
Animalsagingheart10 weeksmales
Pflugers Archiv : European journal of physiology
Moderate endurance exercise
downin rats1
1 study
Moderate endurance exercise
downin rats1
Moderate endurance exercise decreases left ventricular end-diastolic pressure in waterpipe smoking-exposed rats.
“Exercise training normalized the left ventricular end diastolic pressure, +dP/dt max, and contractility index.”
Animalsin waterpipe smoking-exposed ratsheart8 weeks
Frontiers in physiology
Associations
3Kansas City Cardiomyopathy Questionnaire Overall Summary score
downin humans1
1 study
Kansas City Cardiomyopathy Questionnaire Overall Summary score
downin humans1
Left ventricular end-diastolic pressure is associated with Kansas City Cardiomyopathy Questionnaire Overall Summary score in patients with elevated LVEDP (>18 mm Hg) (26.5% <80, mean 85 ± 20).
“Of 653 KCCQ-OS scores collected (mean 85 ± 20), 31.4% had a KCCQ-OS of 100 (asymptomatic), and 26.5% had a KCCQ-OS <80, consistent with NYHA functional class II-IV.”
Humansin patients with elevated LVEDP (>18 mm Hg)n = 653
Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure
JACC. Advances
More on Kansas City Cardiomyopathy Questionnaire Overall Summary score
Chronic kidney disease
upin humans1
1 study
Chronic kidney disease
upin humans1
Chronic kidney disease is associated with left ventricular end-diastolic pressure in outpatients screened with Vivio System (P < 0.01).
“Older patients, women, and those with CKD were more likely to have an elevated LVEDP (P < 0.01 for all).”
Humansin outpatients screened with Vivio Systemn = 2,040
Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure
JACC. Advances
Vivio system
upin humans1+39%
1 study
Vivio system
upin humans1+39%
Vivio system is associated with left ventricular end-diastolic pressure in humans (outpatients at risk for HF (diabetes mellitus, chronic kidney disease, or suspected HF)) (38.5%).
“Among 2,040 screened patients (mean age 74 ± 8 years; 49.8% women; 64.6% with diabetes mellitus; and 34.9% with CKD), 38.5% had an elevated LVEDP.”
Humansoutpatients at risk for HF (diabetes mellitus, chronic kidney disease, or suspected HF)49.8% womensn = 2,040
Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure
JACC. Advances