HorvathAgeAccel

2 papers3 findings

Interventions

Solar and geomagnetic activities

downin humans1

1 study

Solar and geomagnetic activities decrease HorvathAgeAccel in humans (0.61-year lower HorvathAgeAccel).
“Each interquartile range increase in SSN corresponded to a 0.61-year lower HorvathAgeAccel”
Humansbloodinterquartile range increase30-day moving averagemales
Space-Earth connection: How space weather fluctuations impact epigenetic aging in an elderly men cohort from Massachusetts, USA
medRxiv : the preprint server for health sciences13 Nov 2025Preprint

Galactic cosmic rays

upin humans1

1 study

Galactic cosmic rays increase HorvathAgeAccel in humans (0.32-year greater HorvathAgeAccel).
“higher neutron counts were associated with 0.32-year greater HorvathAgeAccel”
Humansblood30-day moving averagemales
Space-Earth connection: How space weather fluctuations impact epigenetic aging in an elderly men cohort from Massachusetts, USA
medRxiv : the preprint server for health sciences13 Nov 2025Preprint

NfL

no changein humans1

1 study

HorvathAgeAccel has no effect on NfL in humans.
“first-generation DNA methylation-based clocks, including HorvathAgeAccel and HannumAgeAccel, were not significantly related to neurofilament light chain.”
HumansControlling for financial strain, exercise, age, gender, cell-type composition, and APOE-ε4
Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study
Aging advances6 Feb 2025