GrimAgeAccel

3 papers5 findings

Interventions

Cumulative socioeconomic status risk

no changein humans1upin humans1

1 study

Cumulative socioeconomic status risk has no effect on GrimAgeAccel in humans.
“Cumulative SES risk was not associated with accelerated aging among women with higher mastery.”
Humansamong women with higher masteryfemalesn = 334
Mastery moderates the association between cumulative socioeconomic status risk and accelerated biological aging among middle-aged Black American women
The journals of gerontology. Series B, Psychological sciences and social sciences9 Sep 2026
Cumulative socioeconomic status risk increases GrimAgeAccel in humans (0.53 years (6.4 months) per risk factor).
“each additional risk factor was associated with an increase in GrimAgeAccel of approximately 0.53 years”
Humansafter accounting for confoundersfemalesn = 334
Mastery moderates the association between cumulative socioeconomic status risk and accelerated biological aging among middle-aged Black American women
The journals of gerontology. Series B, Psychological sciences and social sciences9 Sep 2026

Suicide attempt

upin humans1

1 study

Suicide attempt is associated with GrimAgeAccel in humans (p = 0.008).
“Within the BD individuals, BD/non-SA and BD/SA differed on GrimAgeAccel in both cohorts (p = 0.008) after covariate adjustment.”
Humansin BD individuals across discovery and replication cohorts, adjusted for covariates
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology6 Mar 2023

Birthweight

downin humans1

1 study

GrimAgeAccel is associated with birthweight in humans.
“Higher GrimAgeAccel, b(SE) = - 75.2 (19.7), p < .001; DNAm PAI-1, b(SE) = - .079(.031), p = .013; DNAm ADM, b(SE) = - 13.8 (3.87), p = .001; and DNAm cystatin C, b(SE) = - .010 (.003), p = .001, were also associated with lower birthweight”
Humanswhole bloodfemalesn = 77
Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight
Clinical epigenetics6 Aug 2020

Gestational length

downin humans1

1 study

GrimAgeAccel is associated with gestational length in humans.
“higher early second trimester GrimAgeAccel, b(SE) = - .171 (.056), p = .004; DNAm PAI-1, b(SE) = - 1.95 × 10−4 (8.5 × 10−5), p = .004; DNAm ADM, b(SE) = - .033 (.011), p = .003; and DNAm cystatin C, b(SE) = 2.10 × 10−5 (8.0 × 10−5), p = .012, were each associated with shorter gestational length.”
Humanswhole bloodfemalesn = 77
Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight
Clinical epigenetics6 Aug 2020