Hyaline arteriolosclerosis

1. Hyaline arteriolosclerosis mediates impaired cognitive abilities in humans (β 0.13, 95% CI 0.02-0.22, p = 0.012).

   “The association between impaired cognitive abilities and alcohol consumption was fully mediated by hyaline arteriolosclerosis (β 0.13, 95% CI 0.02-0.22, p = 0.012).”

   Humanseffect of alcohol on cognitionbrain

   Association Between Alcohol Consumption, Cognitive Abilities, and Neuropathologic Changes: A Population-Based Autopsy Study

   Neurology·9 Apr 2025

1. Alcohol is associated with hyaline arteriolosclerosis in humans (OR 2.33, 95% CI 1.50-3.63, p < 0.001).

   “heavy (OR 2.33, 95% CI 1.50-3.63, p < 0.001), and former heavy (OR 1.89, 95% CI 1.41-2.54, p < 0.001) alcohol consumptions were associated with hyaline arteriolosclerosis”

   Humanscompared with participants who never consumed alcoholbrain

   Association Between Alcohol Consumption, Cognitive Abilities, and Neuropathologic Changes: A Population-Based Autopsy Study

   Neurology·9 Apr 2025

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