Limbic-predominant age-related TDP-43 encephalopathy neuropathological change

1. Hippocampal sclerosis is associated with limbic-predominant age-related TDP-43 encephalopathy neuropathological change in humans.

   “Multivariate analysis confirmed associations between HS and LATE‐NC ( p < 0.001)”

   Humansbrain

   Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

   AAIC 2025 abstract·7 Jan 2026

More on Hippocampal sclerosis

1. Hippocampal sclerosis is associated with limbic-predominant age-related TDP-43 encephalopathy neuropathological change in humans (p < 0.001).

   “Multivariate analysis confirmed associations between HS and LATE‐NC ( p < 0.001) as well as lacunar infarcts ( p = 0.031)”

   Humansmultivariate analysisbrain

   Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

   AAIC 2025 abstract·23 Dec 2025

More on Hippocampal sclerosis

1. Limbic-predominant age-related TDP-43 encephalopathy neuropathological change is associated with structural abnormalities in humans (p < 0.05).

   “of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) with hippocampus and amygdala”

   Humanshippocampus and amygdalan = 842

   Neuropathological Correlates of Volume and Shape of Deep Gray Matter Structures in Community-Based Older Adults

   Human brain mapping·1 Jul 2025