Developmental Cell·Jun 17CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched SignalingExperiments in wormsTGF-β signalingPaper
International Journal of Molecular Sciences·Apr 25Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone LossExperiments in miceBones and jointsPaper
Aging·Apr 3Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathwayExperiments in human cellsmTOR signalingPaper
Cell Reports·Feb 27Hedgehog Signaling Modulates Glial Proteostasis and LifespanExperiments in fliesProteostasisPaper
bioRxiv·Feb 6Hedgehog Signalling Modulates Glial Proteostasis and LifespanPreprint: experiments in fliesProteostasisPaper
Open Biology·Nov 21mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovaryExperiments in fliesNotch signalingPaper
Cells·Nov 17Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In VitroExperiments in human cellsMechanismsPaper
Leukemia·Nov 16Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cellsExperiments in cellsDNA damage responsePaper
Aging Cell·Jul 11Chondrocyte-like nested cells in the aged intervertebral disc are late-stage nucleus pulposus cellsExperiments in miceMechanismsPaper
Molecular Therapy·May 14An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2Experiments in human cellsMechanismsPaper
Cell Death and Differentiation·Apr 20PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activationExperiments in mouse cellsMechanismsPaper
Experimental Neurology·Nov 6Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexusExperiments in animalsInterventionsPaper
Translational Research·Oct 19A small molecule Hedgehog agonist HhAg1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failureExperiments in miceInterventionsPaper
Developmental Cell·Sep 11Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell LifespanExperiments in fliesInsulin/IGF-1 signalingPaper
Open Forum Infectious Diseases·Jul 12Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV CoinfectionStudy in peopleMechanismsPaper
Sexual Medicine Reviews·Apr 11Suppression of Cavernosal Fibrosis in a Rat ModelSystematic reviewInterventionsPaper
Theranostics·Feb 22Delivery of Sonic Hedgehog Gene Repressed Irradiation-induced Cellular Senescence in Salivary Glands by Promoting DNA Repair and Reducing Oxidative StressExperiments in miceInterventionsPaper
Journal of Orthopaedic Research·Jul 15Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferationExperiments in miceInflammationPaper
Stem Cells and Development·Jun 22Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset FibroblastsExperiments in miceInterventionsPaper
Cerebral Cortex·May 5Changes in the Proliferative Program Limit Astrocyte Homeostasis in the Aged Post-Traumatic Murine Cerebral CortexExperiments in miceCellular homeostasisPaper
PNAS·Jul 23Hhip haploinsufficiency sensitizes mice to age-related emphysemaExperiments in miceEmphysemaPaper
The European Respiratory Journal·Jul 9Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosisReviewLungPaper
Development·Apr 29Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regenerationExperiments in zebrafishBones and jointsPaper
In Vivo·Feb 26Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with AgingExperiments in miceBones and jointsPaper
Developmental Cell·Dec 27Imparting regenerative capacity to limbs by progenitor cell transplantationExperiments in frogsInterventionsPaper
Neurobiology of Aging·May 28Modeling hippocampal neurogenesis across the lifespan in seven speciesComputational studyMechanismsPaper