Hedgehog

There are 2 papers on hedgehog in aging research: none in people yet, 2 in animals. The newest story, Nov 4, 2026: “Nutrient-sensing circuit guides gut cell development in flies”.

Biomarker

2 papers study it113 more mention it1 finding

3 new papers in 30 daysSee all 115 papers on hedgehog

  • Model organisms2

Upstream

1

mastermind

downin flies1

1 study
  1. mastermind decreases hedgehog in flies (high mam levels in niche cells).

    “High mam levels in niche cells induce reduced Hedgehog amounts”

    Model organismshigh mam levels in niche cellsniche cells

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

More on mastermind

Funding

9 grants since 2018

National Institute of Diabetes and Digestive and Kidney Diseases$2.1MNational Heart, Lung, and Blood Institute$2.1MNational Institute of General Medical Sciences$106K

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Latest

Dec 2025: 2Jan 2026: 2Feb 2026: 4Mar 2026: 3Apr 2026: 3May 2026: 3Jun 2026: 0Jul 2026: 1Aug 2026: 3Sep 2026: 3Oct 2026: 2Nov 2026: 127 papers in 12 months
bioRxiv

Nutrient-sensing circuit guides gut cell development in flies

Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and…Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and shortened lifespan.

Preprint: fly studyNutrient sensing

See all 115 papers on hedgehog