There is 1 paper on Smn in aging research: none in people yet, 1 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
Worms or flies: a single group. Cells, mice and humans: nothing yet.
- 1 lab in 1 country
- Funders: Mississippi State University and 3 more
- Model organisms1
Upstream
1ATXN1
downin flies1
1 study
ATXN1
downin flies1
ATXN1 decreases Smn in flies (pan-neuronal expression of human Ataxin-1 (82Q)).
“significant decrease in expression of survival motor neuron gene (dsmn) in old (30 d) flies”
Model organismspan-neuronal expression of human Ataxin-1 (82Q)males
Biology
Funding
2 grants since 2018National Institute of Neurological Disorders and Stroke$424KNational Institute on Aging$504K
The Role of SMN in Aging Related Weakness: A Novel Therapeutic Target
National Institute on AgingOhio State University$504K2019–2021
Mechanistic link between GATA factors, SMN, and astrocyte senescence in SMA pathology
National Institute of Neurological Disorders and StrokeMedical College of Wisconsin$193K2018–2021