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mastermind

There is 1 paper on mastermind in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it5 findings

Taxon

See all 1 papers on mastermind

At a glance

The findings reach worms or flies, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 4 more
  • Model organisms1

Effects

4

germline stem cell maintenance

mediatesin flies1

1 study

  1. mastermind mediates germline stem cell maintenance in flies (independently of Notch signaling).

    “we present evidence to support a Notch-independent role for mam in the ovarian germline niche”

    Model organismsindependently of Notch signalingovarian germline niche

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

Cadherin

downin flies1

1 study

  1. mastermind decreases cadherin in flies (high mam levels in niche cells).

    “High mam levels in niche cells induce reduced Hedgehog amounts, a decrease in cadherin levels”

    Model organismshigh mam levels in niche cellsniche cells

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

More on Cadherin

Hedgehog

downin flies1

1 study

  1. mastermind decreases hedgehog in flies (high mam levels in niche cells).

    “High mam levels in niche cells induce reduced Hedgehog amounts”

    Model organismshigh mam levels in niche cellsniche cells

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

More on Hedgehog

Germline stem cell number

downin flies1

1 study

  1. mastermind decreases germline stem cell number in flies (overexpression in young niche cells).

    “we can induce premature GSC loss by overexpressing mam in otherwise young niche cells”

    Model organismsoverexpression in young niche cellsniche cells

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

Associations

1

Niche aging

upin flies1

1 study

  1. mastermind is associated with niche aging in flies.

    “We show that mam is upregulated in aged niche cells”

    Model organismsniche cells

    mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary

    Open biology

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