AgingResearch.NewsJoin free

Government

Papers on Government

2,703 papers141 new in 30 days

Wednesday, November 4

Cell Biomaterials

RNA delivery boosts responses in aged human T cells in the lab

In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.In laboratory experiments, delivering several gene-regulating RNAs together enhanced activation and cell-killing responses in aged human T cells.

Figure from Cell Biomaterials
Human cell studyBlood and immune system
Paper
NPJ Aging

RNA patterns varied with age in human lung and brain tissue

An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.An observational analysis of human lung and brain tissue mapped age-related differences in chemical marks on RNA and how RNA molecules were processed.

Figure from NPJ Aging
Cross-sectional studyLung
Paper

Tuesday, November 3

Neuron

Looser DNA packaging impairs energy supply in aged mouse neurons

Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.Experiments in aged mouse neurons linked oxidative stress to looser mitochondrial DNA packaging, fewer RNA copies from that DNA and impaired energy production.

Figure from Neuron
Animal cell studyMechanisms
Paper
PNAS

Adding a brain RNA improved sperm quality in male mice

In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.In an animal experiment, adding Synage to a brain region increased testosterone, sperm counts and forward sperm movement in 12-month-old mice.

Figure from PNAS
Mouse studyReproductive system
Paper

Monday, November 2

EMBO Reports

Amyloid linked to reduced mitochondrial cleanup in neurons

Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing…Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing structures.

Decreased mitochondrial ceramide levels and altered mitochondrial function in Alzheimer’s disease (AD) models.
Human cell studyInterventions
Paper
Nature Communications

Worms lacking a regulatory protein lived longer on certain diets

Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.

B12 is required for the osmotic stress tolerance (OST) and longevity of rict-1(ft7) worms.
Worm studyMechanisms
Paper

Sunday, November 1

bioRxiv

A persistent virus benefited flies under temperature stress

Experiments in fruit flies found that persistent Nora virus infection extended lifespan and improved reproductive output and behavioral performance under ongoing…Experiments in fruit flies found that persistent Nora virus infection extended lifespan and improved reproductive output and behavioral performance under ongoing temperature stress.

Fruit flies face beneath heat waves; the dark blue-green fly has virus particles and many offspring, while the gray fly has fewer offspring.
Preprint: fly studyMechanisms
Paper

Saturday, October 31

Oncogene

Protein loss curbs colorectal cancer in experiments

Experiments found that losing a mitochondrial regulator induced a state in which cells stop dividing and suppressed colorectal cancer progression.Experiments found that losing a mitochondrial regulator induced a state in which cells stop dividing and suppressed colorectal cancer progression.

Knockdown of SIRT3 induces MIDAS in colorectal cancer cells.
Experiments in cellsMechanisms
Paper
Cell Death & Disease

Virus-based delivery eased obesity or osteoporosis in mice

Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models.Virus-based supplementation of a stem-cell regulator eased obesity, osteoporosis or both across three mouse models.

ITGBL1 is associated with adipogenic and osteogenic differentiation and is downregulated in obesity- and osteoporosis-related lineage imbalance.
Mouse studyOsteoporosis
Paper
Aging Cell

Peptide reduced aging-linked changes in lab-grown cells

Experiments in lab-grown cells tested a peptide that disrupted a protein interaction and reduced senescence, a state in which cells stop dividing.Experiments in lab-grown cells tested a peptide that disrupted a protein interaction and reduced senescence, a state in which cells stop dividing.

USP25 is preferentially accumulated during aging.
Human cell studyMechanisms
Paper