What does the research say about glomerular filtration rate decline?

Glomerular filtration rate decline

There are 2 papers on glomerular filtration rate decline in aging research: 1 observational study in people, 1 review. The newest story, Nov 13, 2026: “Lower income linked to worsening kidney function and death”.

Biomarker

2 papers study it23 more mention it6 findings

7 new papers in 30 daysSee all 25 papers on glomerular filtration rate decline

“individuals with baseline metabolic syndrome had a significant mean of 0.30 ml/min/year faster decline than individuals without metabolic syndrome in a multivariable adjusted linear regression model”

Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general populationKidney international2018doi:10.1016/j.kint.2017.11.012

Humans1

Interventions

GLP-1 receptor agonists

downin humans1

1 study

GLP-1 receptor agonists decrease glomerular filtration rate decline in humans (diabetic kidney disease).
“Randomized clinical trials and real-life analyses have demonstrated reductions in albuminuria and slowing of glomerular filtration rate (GFR) decline.”
Reviewdiabetic kidney diseasekidney
Renal Effects of Glucagon-like Peptide-1 Receptor Agonists in Diabetic Kidney Disease: A Narrative Review of Mechanisms and Clinical Evidence
Medicina (Kaunas, Lithuania)Aug 5, 2026

Associations

Triglyceride

upin humans1

1 study

Triglyceride is associated with glomerular filtration rate decline in humans (triglyceride criterion of metabolic syndrome analyzed separately) (0.36 ml/min/year faster decline).
“This association was mainly driven by the triglyceride criterion of metabolic syndrome, which was associated with a significant 0.36 ml/min/year faster decline when analyzed separately.”
Humanstriglyceride criterion of metabolic syndrome analyzed separatelymedian 5.6 years
Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general population
Kidney internationalFeb 1, 2018

Latest

14 papers in 12 months

MedicinaAug 27

Renal Effects of Glucagon-like Peptide-1 Receptor Agonists in Diabetic Kidney Disease: A Narrative Review of Mechanisms and Clinical Evidence

ReviewGLP-1 receptor agonists

Paper

Kidney InternationalFeb 6

Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general population

Cohort study of 1,261 peopleMetabolic syndrome

Paper

medRxivNov 13

Lower income linked to worsening kidney function and death

Household income below $25,000, versus $200,000 or more, was linked to sustained kidney decline with an adjusted hazard ratio of 3.57.Household income below $25,000, versus $200,000 or more, was linked to sustained kidney decline with an adjusted hazard ratio of 3.57.

Preprint: cohort · 218,098 peopleKidney