Body mass index

5 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Institute on Aging and 1 more

Humans3
In silico1

Associations

Alzheimer's disease and dementia

upin humans1

1 study

Body mass index raises the risk of Alzheimer's disease and dementia in humans.
“high‐SDI countries bearing the greatest burden due to modifiable risk factors like fasting plasma glucose and BMI”
Humansin high-SDI countries
Global Burden of Alzheimer's Disease and Dementia: Trends in Mortality, Risk Factors and Incidence Across Sustainable Development Index Regions from 1990 to 2021
AAIC 2025 abstract23 Dec 2025

More on Alzheimer's disease and dementia

Cardiometabolic multimorbidity

upin humans1

1 study

Body mass index raises the risk of cardiometabolic multimorbidity in humans.
“Both BRI and BMI were independently and linearly associated with an increased risk of CMM.”
Humans12-15 yearsn = 3,348
Body roundness index and cardiometabolic multimorbidity: Findings from the English Longitudinal Study of Ageing
Nutrition, metabolism, and cardiovascular diseases : NMCD27 Nov 2025