Waist-hip ratio

1. Waist-hip ratio is linked with higher deep white matter hyperintensities in humans (Mendelian randomization analysis, stronger in men than in women).

   “MR validated stronger causal effects of waist-hip ratio on deep WMH in men than in women (P<0.001).”

   HumansMendelian randomization analysis, stronger in men than in womenmales

   Obesity, White Matter Hyperintensities, and Cognitive Decline: Sex-Specific DTI-ALPS Index Mediation

   Stroke·Jun 18, 2026

More on Deep white matter hyperintensities

1. Waist-hip ratio was not clearly linked with glomerular filtration rate decline in humans.

   “Neither the body mass index, waist circumference nor waist-hip ratio predicted statistically significant changes in age-related GFR decline”

   Humansmedian 5.6 years

   Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general population

   Kidney international·Feb 1, 2018

More on Glomerular filtration rate decline

1. Waist-hip ratio is associated with complex processing speed in humans (highest vs lowest WHR tertile (T3 vs T1), cross-sectional, after full covariate adjustment) (β = -0.091 (95% CI -0.115 to -0.068); p_BH <0.001).

   “processing (β = -0.091, 95% CI: -0.115 to -0.068, p_BH <0.001)”

   Humanshighest vs lowest WHR tertile (T3 vs T1), cross-sectional, after full covariate adjustmentn = 72,899

   Associations between obesity indices and cognitive function: Evidence from a middle-aged observational and Mendelian randomisation study

   Diabetes, obesity & metabolism·Nov 5, 2025

1. Waist-hip ratio is linked with a higher risk of poor cognitive performance in humans (WHR ≥0.90 versus <0.90) (OR 1.233).

   “Male WHR > = 0.90 had a higher risk of poor cognitive performance than male WHR < 0.90 (odds ratio [OR] = 1.233; p = 0.007)”

   HumansWHR ≥0.90 versus <0.90malesn = 12,094

   Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

   BMC geriatrics·Nov 7, 2022

1. Waist-hip ratio is associated with GrimEAA in humans (0.481-year GrimEAA).

   “an increase of one SD in waist-hip ratio (0.06) was associated with a 0.602-year PhenoEAA (p = 6.3E-6) and a 0.481-year GrimEAA (p = 1.2E-8).”

   Humansone SD (0.06)males

   Associations of five obesity metrics with epigenetic age acceleration: Evidence from 2,474 Taiwan Biobank participants

   Obesity (Silver Spring, Md.)·Sep 2, 2021

More on GrimEAA

1. Waist-hip ratio is associated with PhenoEAA in humans (0.602-year PhenoEAA).

   “For male individuals, an increase of one SD in waist-hip ratio (0.06) was associated with a 0.602-year PhenoEAA (p = 6.3E-6)”

   Humansone SD (0.06)males

   Associations of five obesity metrics with epigenetic age acceleration: Evidence from 2,474 Taiwan Biobank participants

   Obesity (Silver Spring, Md.)·Sep 2, 2021

More on PhenoEAA

1. Waist-hip ratio is linked with a higher risk of nephrolithiasis in humans (HR 1.13 (95% CI 1.01, 1.27)).

   “High waist-hip ratio (≥0.80 and ≥0.90 for women and men, respectively) was associated with risk”

   Humans≥0.80females

   Nephrolithiasis Among Middle Aged and Elderly Urban Chinese: A Report from Prospective Cohort Studies in Shanghai

   Journal of endourology·Oct 20, 2017

More on Nephrolithiasis

1. Waist-hip ratio is linked with a higher risk of hip fracture in humans (dose-response, per 0.1 unit increment) (about 3.0% per 0.1 unit increment; RR 1.03 (1.01-1.04)).

   “the risk of hip fracture increased about 3.0% (1.03 (1.01-1.04)) for each 0.1 unit increment of waist-hip ratio”

   Humansdose-response, per 0.1 unit increment0.1 unit increment

   Abdominal obesity and risk of hip fracture: a meta-analysis of prospective studies

   Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jul 12, 2017

More on Hip fracture