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FTO expression

Biomarker

2 papers2 findings

  • Humans1
  • Cells1

Upstream

2

DNMT1

downin rat cells1

1 study

  1. DNMT1 decreases FTO expression in rat cells.

    “DNMT1 suppresses FTO expression by promoting Fto promoter methylation.”

    Cellsthrough Fto promoter methylationLeydig cell

    Protein promotes testosterone production in rat cells

    Aging cell1 Oct 2026

More on DNMT1

SIRT1

downin cells1

1 study

  1. SIRT1 decreases FTO expression in cells.

    “activated SIRT1 inhibited the expression of FTO through deacetylating RANBP2”

    Cellsthrough RANBP2 deacetylationbone marrow mesenchymal stem cell

    Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis

    Cell death discovery25 Feb 2026

More on SIRT1

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Aging Cell

Protein promotes testosterone production in rat cells

Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.Increasing the protein’s production in rat cells grown in the lab restored testosterone output and reversed signs of senescence, a state in which cells stop dividing.

Experiments in rat cellsMechanisms
Paper

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