bioRxiv
Blocking a receptor lets a hormone spur mouse heart cell division
Experiments in newborn mouse heart cells found that blocking one hormone receptor allowed corticosterone to promote division through another, with effects depending on…Experiments in newborn mouse heart cells found that blocking one hormone receptor allowed corticosterone to promote division through another, with effects depending on surrounding cells.
Preprint: animal cell studyMechanisms
Who was studiedPrimary neonatal cardiomyocytes, 48 hours, against control cultures
What changedCorticosterone increased cardiomyocyte proliferation in receptor-deficient cultures, but suppressed proliferation in control cultures
The catchCardiomyocyte proliferation was measured; cardiac function and regeneration were not measured