Extracellular matrix markers

2 papers1 finding

Humans1
Cells1

Interventions

1

Senolytics

downin mouse cells1

1 study

Senolytics decrease extracellular matrix markers in mouse cells.
“reduced SASP factors and extracellular matrix markers, while increasing alveolar epithelial markers.”
Cellsin fibrotic ATII cells or ex vivo three-dimensional lung tissue cultures
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
The European respiratory journalAug 3, 2017

More on Senolytics

Latest

3 in 12 months

American Journal of Physiology Cell PhysiologyJul 29

Dysregulated iron metabolism in remodeling of aging asthmatic human airways

Study in peopleExtracellular matrix remodelling

PhytomedicineMar 1

Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation

Experiments in miceKnee osteoarthritis

Journal of NeuroinflammationNov 19

Age-related inflammatory changes and perineuronal net dynamics: implications for aging

Experiments in miceInflammation

bioRxivSep 26

Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders

Preprint: experiments in miceInflammation

bioRxivJan 22

IGFBP2 protects against pulmonary fibrosis through inhibiting P21-mediated senescence

Preprint: experiments in animalsMechanisms

The European Respiratory JournalAug 3

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

Experiments in human cellsSenolytics